Papers - KITATANI Kazuyuki
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Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decrease responsiveness to signaling by the CXCL12/CXCR4 pathway
Asano S., Kitatani K., Taniguchi M., Hashimoto M., Zama K., Mitsutake S., Igarashi Y., Takeya H., Hayashi A., Umehara H., Kigawa J., and Okazaki T.
Mol. Cell. Biol. 2012
Joint Work
Research paper (scientific journal)
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Identification and characterization of PP2C activation by ceramid
Perry. D.M., Kitatani K., Roddy P., El-Osta M., Hannun Y.A.
J. Lipid Res. 2012
Joint Work
Research paper (scientific journal)
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Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats
Tsounapi P., Saito M., Kitatani K., Dimitriadis F., Ohmasa F., Shimizu S., Kinoshita Y., Takenaka A., Satoh K.
Eur. J. Pharmacol. 2012
Joint Work
Research paper (scientific journal)
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Regulation of autophagy and its associated cell death by sphingolipid rheostat: Reciprocal role in ceramide and sphingosine-1-phosphate in the mTOR pathway
Taniguchi M., Kitatani K., Kondo T., Hashimoto-Nishimura M., Asano S., Hayashi A., Mitsutake S., Igarashi Y., Umehara H., Takeya H., Kigawa J. and Okazaki T.
J. Biol. Chem. 2012
Joint Work
Research paper (scientific journal)
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C型慢性肝炎の治療薬開発を通してみた国内外の臨床試験検索サイトの活用方法の模索
平田みよ，浦野義崇，稲葉繁樹,北谷和之,岡崎俊朗，北垣浩志
医薬品医療機器レギュラトリーサイエンス 2012
Joint Work
Research paper (scientific journal)
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Phospholipase C and protein kinase C2 mediate insulin-like growth factor 2-dependent sphingosine kinase 1 activation
El-Shewy H.M., Abdel-Samie S.A., Al Qalam A.M., Lee M.H., Kitatani K., Anelli V., Jaffa A.A., Obeid L.M., Luttrell L.M.
Mol. Endocrinol. 2011
Joint Work
Research paper (scientific journal)
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Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice
, Fujiwara K., Kitatani K., Fukushima K., Yazama H., Umehara H., Kikuchi M., Igarashi Y., Kitano H., and Okazaki T.
Int. J. Clin. Oncol. 2011
Joint Work
Research paper (scientific journal)
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Selective knockdown of ceramide synthases reveals complex inter-regulation of sphingolipid metabolism
Mullen T.D., Spassieva S., Jenkins R.W., Kitatani K., Bielawski J., Hannun Y.A., and Obeid L.M.
J. Lipid Res. 2011
Joint Work
Research paper (scientific journal)
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Regulation of CC ligand 5/rantes by acid sphingomyelinase
Jenkins R.W., Clarke C.J., Canal D., Snider A.J., Gault C.R., Heffernan-Stroud L., Wu B.X., Simbari F., Roddy P., Kitatani K., Obeid L.M., and Hannun Y.A.
J. Biol. Chem. 2011
Joint Work
Research paper (scientific journal)
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Isofagomine in vivo effects in a neuropathic Gaucher disease mouse
Sun Y., Ran H., Liou B., Quinn B., Zamzow M., Zhang W., Bielawski J., Kitatani K., Setchell K.D., Hannun Y.A., Witte D.P., Xu Y., and Grabowski G.A.
PLoS One 2011
Joint Work
Research paper (scientific journal)
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SMS1-generated sphingomyelin plays an important role in transferring trafficking and cell proliferation
Kitatani K., Abdel Shakor A.B., Taniguchi M., Hashimoto M., Asano S., Hayashi A., Nomura K., Bielawski J., Bielawska A., Watanabe K., Kobayashi T., Igarashi Y., Umehara H., Takeya H., and Okazaki T.
J. Biol. Chem. 2011
Joint Work
Research paper (scientific journal)
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酒粕に含まれるスフィンゴ脂質の検出•半定量的評価とその由来の解析
牧江俊雄，黒田祥平,中村剛，今井優樹，森永紀，北谷和之
J. Brew. Soc. Japan. 2011
Joint Work
Research paper (scientific journal)
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Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation
Jenkins R.W., Canal D., Idkowiak-Baldys J., Simbari F., Roddy P. Perry D.M., Kitatani K., Luberto C., and Hannun Y.A.
J. Biol. Chem. 2010
Joint Work
Research paper (scientific journal)
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Neuronopathic Gaucher disease in the mouse: Viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) with CNS glucosylsphingosine and glucosylceramide accumulation
Sun Y., Liou B., Ran H., Skelton M.R., Williams M.T., Vorhees C.V., Kitatani K., Hannun Y.A., Witte D.P., Xu Y., and Grabowski G.A.
Human Mol. Genet. 2010
Joint Work
Research paper (scientific journal)
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Specific saposin C deficiency: CNS impairment and acid--glucosidase effects in the mouse
Sun Y., Ran H., Zamzow M., Kitatani K., Skelton M.R., Williams M.T., Vorhees C.V., Witte D.P., Hannun Y.A., and Grabowski G.A.
Human Mol. Genet. 2010
Joint Work
Research paper (scientific journal)
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Acid--glucosidase 1 counteracts p38-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
Kitatani K., Sheldon, K., Anelli, V., Jenkins, R. W., Sun, Y., Grabowski, G. A., Obeid, L. M., and Hannun, Y. A.
J. Biol. Chem. 2009
Joint Work
Research paper (scientific journal)
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Involvement of acid--glucosidase 1 in the salvage pathway of ceramide formation.
Kitatani K., Sheldon, K., Anelli, V., Jenkins, R. W., Sun, Y., Grabowski, G. A., Obeid, L. M., and Hannun, Y. A.
J. Biol. Chem. 2009
Joint Work
Research paper (scientific journal)
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DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells
Sundra S.,Mani S.K., Kitatani K., Wu. K., Pestell R.G., and Reddy. S.V.
J. Cell. Biochem. 2008
Joint Work
Research paper (scientific journal)
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Mechanism of inhibition of sequestration of protein kinase C /ßII by ceramide: roles of ceramide activated protein phosphatases and phosphorylation/dephosphorylation of PKC/II on threonine 638/641.
Kitatani K., Idkowiak-Baldys J., and Hannun Y.A.
J. Biol. Chem. 2007
Joint Work
Research paper (scientific journal)
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Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.
Taha T. A., Kitatani K., El-Alwani M., Bielawski J., Hannun Y. A., and Obeid L. M.
FASEB J. 2006
Joint Work
Research paper (scientific journal)