Papers - KITATANI Kazuyuki

Pronecroptotic Therapy Using Ceramide Nanoliposomes Is Effective for Triple-Negative Breast Cancer Cells International coauthorship

Yuki Ohya, Yuri Ogiso, Masaya Matsuda, Harumi Sakae, Kentaro Nishida, Yasuhiro Miki, Todd E Fox, Mark Kester, Wataru Sakamoto, Takeshi Nabe, Kazuyuki Kitatani

Cells13 ( 5 ) 405   2024.02

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

Involvement of Janus kinase-dependent Bcl-xL overexpression in steroid resistance of group 2 innate lymphoid cells in asthma

Masaya Matsuda, Hayato Shimora, Yukino Nagatani, Keitaro Nishikawa, Itomi Takamori, Tenta Haguchi, Kazuyuki Kitatani, Osamu Kaminuma, Takeshi Nabe

Immunology172   653 - 668   2024.08

Joint Work

Research paper (scientific journal)

Involvement of CCR5 on interstitial macrophages in the development of lung fibrosis in severe asthma

Masaya Matsuda, Hayato Shimora, Yukino Nagatani, Keitaro Nishikawa, Itomi Takamori, Tenta Haguchi, Kazuyuki Kitatani, Osamu Kaminuma, Takeshi Nabe

International Immunopharmacology135   112331   2024.06

Joint Work

Research paper (scientific journal)

Steroid-Insensitive Gene Expression of Extracellular Matrix Components and Pro-fibrotic Factors in the Lung Associated with Airway Hyperresponsiveness in Murine Asthma

Hayato Shimora, Masaya Matsuda, Naoki Takemoto, Miku Nomura, Junpei Hamaguchi, Ryogo Terakawa, Miki Inaba, Kazuyuki Kitatani, Takeshi Nabe

Biological and Pharmaceutical Bulletin47 ( 1 ) 227 - 231   2024

Joint Work

Research paper (scientific journal)

Ceramide Nanoliposomes as Potential Therapeutic Reagents for Asthma.

Harumi Sakae, Yuri Ogiso, Masaya Matsuda, Hayato Shimora, Tye Deering, Todd E Fox, Mark Kester, Takeshi Nabe, Kazuyuki Kitatani

Cells12   591   2023.02

Joint Work

Research paper (scientific journal)

Extracellular Vesicles Derived from Allergen Immunotherapy-Treated Mice Suppressed IL-5 Production from Group 2 Innate Lymphoid Cells

Masaya Matsuda, Seito Shimizu, Kazuyuki Kitatani, Takeshi Nabe

Pathogens 11   1373   2022.11

Joint Work

Research paper (scientific journal)

Local IL-10 replacement therapy was effective for steroid-insensitive asthma in mice

Masaya Matsuda, Miki Inaba, Junpei Hamaguchi, Hiro Tomita, Miyu Omori, Hayato Shimora, Harumi Sakae, Kazuyuki Kitatani, Takeshi Nabe

International Immunopharmacology110   2022.09

Joint Work

Research paper (scientific journal)

Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells

Keiko Tamiya-Koizumi, Yurika Otoki, Kiyotaka Nakagawa, Reiji Kannagi, Naoki Mizutani, Motoshi Suzuki, Mamoru Kyogashima, Soichiro Iwaki, Mineyoshi Aoyama, Takashi Murate, Kazuyuki Kitatani, Takahisa Kuga , Yasuyoshi Mizutani, Akira Tokumura

Biochemical and Biophysical Research Communications611   1 - 7   2022.06

Joint Work

Research paper (scientific journal)

Involvement of small extracellular vesicle-derived TIE-1 in the chemoresistance of ovarian cancer cells

Tomoka Misawa , Masafumi Toyoshima , Kazuyuki Kitatani , Masumi Ishibashi , Junko Hasegawa-Minato , Shogo Shigeta , Nobuo Yaegashi

Cancer Treatment and Research Communications27   100364   2021.03

Joint Work

Research paper (scientific journal)

DOI

Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.

Xuewei Zhang , Wataru Sakamoto , Daniel Canals , Masumi Ishibashi , Masaya Matsuda , Kentaro Nishida , Masafumi Toyoshima , Shogo Shigeta , Makoto Taniguchi , Can E Senkal , Toshiro Okazaki , Nobuo Yaegashi , Yusuf A Hannun , Takeshi Nabe , Kazuyuki Kitatani

FASEB Journal35 ( 2 ) e21287   2021.02

Joint Work

Research paper (scientific journal)

DOI

Study Profile of The Tohoku Medical Megabank Community-Based Cohort Study

Hozawa A , Tanno K , Nakaya N , Nakamura T , Tsuchiya N , Hirata T , Narita A , Kogure M , Nochioka K , Sasaki R , Takanashi N , Otsuka K , Sakata K , Kuriyama S , Kikuya M , Tanabe O , Sugawara J , Suzuki K , Suzuki Y , Kodama EN , Fuse N , Kiyomoto H , Tomita H , Uruno A , Hamanaka Y , Metoki H , Ishikuro M , Obara T , Kobayashi T , Kitatani K , Takai-Igarashi T , Ogishima S , Satoh M , Ohmomo H , Tsuboi A , Egawa S , Ishii T , Ito K , Ito S , Taki Y , Minegishi N , Ishii N , Nagasaki M , Igarashi K , Koshiba S , Shimizu R , Tamiya G , Nakayama K , Motohashi H , Yasuda J , Shimizu A , Hachiya T , Shiwa Y , Tominaga T , Tanaka H , Oyama K , Tanaka R , Kawame H , Fukushima A , Ishigaki Y , Tokutomi T , Osumi N , Kobayashi T , Nagami F , Hashizume H , Arai T , Kawaguchi Y , Higuchi S , Sakaida M , Endo R , Nishizuka S , Tsuji I , Hitomi J , Nakamura M , Ogasawara K , Yaegashi N , Kinoshita K , Kure S , Sakai A , Kobayashi S , Sobue K , Sasaki M , Yamamoto M

Journal of Epidemiology31 ( 1 ) 65 - 76   2021.01

Joint Work

Research paper (scientific journal)

Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects

1) Tetsuya Terada, Masaya Matsuda, Miki Inaba, Junpei Hamaguchi, Naoki Takemoto, Yusuke Kikuoka, Yuko Inaka, Harumi Sakae, Kennosuke Hashimoto, Hayato Shimora, Kazuyuki Kitatani, Ryo Kawata, Takeshi Nabe

Inflamm Res70   581 - 589   2021

Joint Work

Research paper (scientific journal)

Pathogenic changes in group 2 innate lymphoid cells (ILC2s) in a steroid-insensitive asthma model of mice.

Masaya Matsuda, Yoshiyuki Tanaka, Hayato Shimora, Naoki Takemoto, Miku Nomura, Ryogo Terakawa, Kennosuke Hashimoto, Harumi Sakae, Akira Kanda, Hiroshi Iwai, Kazuyuki Kitatani, Takeshi Nabe

Eur J Pharmacol916   174732   2021

Joint Work

Research paper (scientific journal)

dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project

Ogishima S, Nagaie S, Mizuno S, Ishiwata R, Iida K, Shimokawa K, Takai-Igarashi T, Nakamura N, Nagase S, Nakamura T, Tsuchiya N, Nakaya N, Murakami K, Ueno F, Onuma T, Ishikuro M, Obara T, Mugikura S, Tomita H, Uruno A, Kobayashi T, Tsuboi A, Tadaka S, Katsuoka F, Narita A, Sakurai M, Makino S, Tamiya G, Aoki Y, Shimizu R, Motoike IN, Koshiba S, Minegishi N, Kumada K, Nobukuni T, Suzuki K, Danjoh I, Nagami F, Tanno K, Ohmomo H, Asahi K, Shimizu A, Hozawa A, Kuriyama S; Tohoku Medical Megabank Project Study Group (Kitatani K Fuse N, Tominaga T, Kure S, Yaegashi N, Kinoshita K, Sasaki M, Tanaka H, Yamamoto M

Hum Genome Var10   44   2021

Joint Work

Research paper (scientific journal)

Importance of the Azole moiety of cimetidine derivatives for the inhibition of human multidrug and toxin extrusion transporter 1 (hMATE1)

Susumu Shinya, Kentaro Kawai, Atsushi Tarui, Yukiko Karuo, Kazuyuki Sato, Masaya Matsuda, Kazuyuki Kitatani, Naoki Kobayashi, Takeshi Nabe, Masato Otsuka, Masaaki Omote

Chem Pharm Bull (Tokyo)69   905 - 912   2021

Joint Work

Research paper (scientific journal)

Analyses of regulatory T cells and regulatory B cells in subcutaneous immunotherapy-treated allergic individuals in human and mice

Masaya Matsuda, Testuya Terada, Kazuyuki Kitatani, Ryo Kawata, Takeshi Nabe

Japanese Journal of Ocular Pharmacology34   87 - 89   2020.08

Joint Work

Research paper (other academic)

Potential of Tyrosine Kinase Receptor TIE-1 as Novel Therapeutic Target in High-PI3K-Expressing Ovarian Cancer

Xuewei Zhang , Masumi Ishibashi , Kazuyuki Kitatani , Shogo Shigeta , Hideki Tokunaga , Masafumi Toyoshima , Muneaki Shimada , Nobuo Yaegashi

Cancers12 ( 6 ) 1705   2020.06

Joint Work

Research paper (scientific journal)

DOI

C6-ceramide Inhibits the Motility of Anaplastic Thyroid Carcinoma Cells

Kazunori Fujiwara , Hiroaki Yazama , Ryohei Donishi , Satoshi Koyama , Takahiro Fukuhara , Kazuyuki Kitatani , Hideyuki Kataoka , Hiromi Takeuchi

Yonago Acta Medica63   95 - 98   2020.05

Joint Work

Research paper (scientific journal)

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

5. Shinichi Kuriyama, Hirohito Metoki, Masahiro Kikuya, Taku Obara, Mami Ishikuro, Chizuru Yamanaka, Masato Nagai, Hiroko Matsubara, Tomoko Kobayashi, Junichi Sugawara, Gen Tamiya, Atsushi Hozawa, Naoki Nakaya, Naho Tsuchiya, Tomohiro Nakamura, Akira Narita, Mana Kogure, Takumi Hirata, Ichiro Tsuji, Fuji Nagami, Nobuo Fuse, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Yoichi Suzuki, Noriko Osumi, Keiko Nakayama, Kiyoshi Ito, Shinichi Egawa, Koichi Chida, Eiichi Kodama, Hideyasu Kiyomoto, Tadashi Ishii, Akito Tsuboi, Hiroaki Tomita, Yasuyuki Taki, Hiroshi Kawame, Kichiya Suzuki, Naoto Ishii, Soichi Ogishima, Satoshi Mizuno, Takako Takai-Igarashi, Naoko Minegishi, Jun Yasuda, Kazuhiko Igarashi, Ritsuko Shimizu, Masao Nagasaki, Osamu Tanabe, Seizo Koshiba, Hiroaki Hashizume, Hozumi Motohashi, Teiji Tominaga, Sadayoshi Ito, Kozo Tanno, Kiyomi Sakata, Atsushi Shimizu, Jiro Hitomi, Makoto Sasaki, Kengo Kinoshita, Hiroshi Tanaka, Tadao Kobayashi, The Tohoku Medical Megabank Project Study Group, Shigeo Kure, Nobuo Yaegashi, Masayuki Yamamoto; Tohoku University Tohoku Medical Megabank Organization (ToMMo) Study Group Members: Michiaki Abe, Yayoi Aizawa, Yuichi Aoki, Koichi Chida, Inaho Danjoh, Shinichi Egawa, Ai Eto, Takamitsu Funayama, Nobuo Fuse, Yohei Hamanaka, Yuki Harada, Hiroaki Hashizume, Shinichi Higuchi, Sachiko Hirano, Takumi Hirata, Masahiro Hiratsuka, Atsushi Hozawa, Kazuhiko Igarashi, Jin Inoue, Noriko Ishida, Naoto Ishii, Tadashi Ishii, Mami Ishikuro, Kiyoshi Ito, Sadayoshi Ito, Maiko Kageyama, Fumiki Katsuoka, Hiroshi Kawame, Junko Kawashima, Masahiro Kikuya, Kengo Kinoshita, Kazuyuki Kitatani, Tomomi Kiyama, Hideyasu Kiyomoto, Tomoko Kobayashi, Eiichi Kodama, Mana Kogure, Kaname Kojima, Sachie Koreeda, Seizo Koshiba, Shihoko Koyama, Hisaaki Kudo, Kazuki Kumada, Shigeo Kure, Miho Kuriki, Shinichi Kuriyama, Yoko Kuroki, Norihide Maikusa, Satoshi Makino, Hiroko Matsubara, Hiroyuki Matsui, Hirohito Metoki, Takahiro Mimori, Naoko Minegishi, Kazuharu Misawa, Masako Miyashita, Satoshi Mizuno, Hozumi Motohashi, Ikuko N. Motoike, Keiko Murakami, Satoshi Nagaie, Masato Nagai, Fuji Nagami, Masao Nagasaki, Sachiko Nagase, Naoki Nakamura, Tomohiro Nakamura, Naoki Nakaya, Keiko Nakayama, Akira Narita, Ichiko Nishijima, Takahiro Nobukuni, Kotaro Nochioka, Taku Obara, Soichi Ogishima, Noriaki Ohuchi, Gervais Olivier, Noriko Osumi, Hiroshi Otsu, Akihito Otsuki, Daisuke Saigusa, Sakae Saito, Tomo Saito, Masaki Sakaida, Mika Sakurai-Yageta, Yuki Sato, Yukuto Sato, Atsushi Sekiguchi, Chen-Yang Shen, Tomoko F. Shibata, Ritsuko Shimizu, Kazuro Shimokawa, Matsuyuki Shirota, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Shu Tadaka, Makiko Taira, Takako Takai-Igarashi, Yuji Takano, Yasuyuki Taki, Gen Tamiya, Osamu Tanabe, Hiroshi Tanaka, Yukari Tanaka, Shunsuke Teraguchi, Takahiro Terakawa, Teiji Tominaga, Hiroaki Tomita, Akito Tsuboi, Naho Tsuchiya, Ichiro Tsuji, Masao Ueki, Akira Uruno, Nobuo Yaegashi, Junya Yamagishi, Yumi Yamaguchi-Kabata, Chizuru Yamanaka, Riu Yamashita, Jun Yasuda, Junji Yokozawa and Kazunori Waki. Iwate Medical University Iwate Tohoku Medical Megabank Organization (IMM) Study Group Members: Junko Akai, Ryujin Endo, Akimune Fukushima, Ryohei Furukawa, Tsuyoshi Hachiya, Kouhei Hashizume, Jiro Hitomi, Yasushi Ishigaki, Shohei Komaki, Yuka Kotozaki, Takahiro Mikami, Motoyuki Nakamura, Naoyuki Nishiya, Satoshi Nishizuka, Yoko Nomura, Kuniaki Ogasawara, Hideki Ohmomo, Shinichi Omama, Ryo Otomo, Kotaro Otsuka, Kotaro Oyama, Kiyomi Sakata, Ryohei Sasaki, Mamoru Satoh, Namie Sato, Atsushi Shimizu, Yu Shiwa, Yoichi Sutoh, Nobuyuki Takanashi, Noriko Takebe, Fumitaka Tanaka, Ryoichi Tanaka, Kozo Tanno, Tomoharu Tokutomi, Kayono Yamamoto, and Fumio Yamashita

International Journal of Epidemiology49   18m - 19m   2020.02

Joint Work

Research paper (scientific journal)

Adoptive transfer of type 1 regulatory T cells suppressed the development of airway hyperresponsiveness in ovalbumin-induced airway inflammation model mice

Matsuda M, Doi K, Tsutsumi T, Inaba M, Hamaguchi J, Terada T, Kawata R, Kitatani K, Nabe T

Journal of Pharmacological Sciences141 ( 4 ) 139 - 145   2019.12

Joint Work

Research paper (scientific journal)

Regulation of Cell Motility by La-Related Protein 4 in Ovarian Cancer Cells

Mahy Egiz, Toshinori Usui, Masumi Ishibashi, Xuewei Zhang, Shogo Shigeta, Masafumi Toyoshima, Kazuyuki Kitatani, Nobuo Yaegashi

Tohoku Journal Experimental Medicine247   59 - 67   2019.01

Joint Work

Research paper (scientific journal)

Tyrosine kinase receptor TIE-1 mediates platinum resistance by promoting nucleotide excision repair in ovarian cancer.

Ishibashi M, Toyoshima M, Zhang X, Hasegawa-Minato J, Shigeta S, Usui T, Kemp CJ, Grandori C, Kitatani K, Yaegashi N

Scientific Reports8   13207   2018

Joint Work

Research paper (scientific journal)

DOI

Novel cooperative pathway of c-Myc and Furin, a pro-protein convertase, in cell proliferation as a therapeutic target in ovarian cancers

Hasegawa-Minato J, Toyoshima M., Ishibashi M., Zhang X., Shigeta S., Grandori C., Kitatani K. and Yaegashi N

Oncotarget   2018

Joint Work

Research paper (scientific journal)

Ceramide nanoliposomes as a MLKL-dependent, necroptosis-inducing, chemotherapeutic reagent in ovarian cancer.

Zhang X., Kitatani K., Toyoshima M., Ishibashi M., Usui T., Minato J., Egiz M., Shigeta S., Fox T., Deering T., Kester M., and Yaegashi N.

Mol. Cancer Ther.   2018

Joint Work

Research paper (scientific journal)

がん転移学の基礎研究：卵巣癌の分子機構

渋谷祐介，重田昌吾，伊藤潔，北谷和之，八重樫伸生

日本臨床   2017

Joint Work

Research paper (scientific journal)

p38delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment Activation of p38 mitogen-activated protein kinase in Gaucher’s disease

Wada M.,その他10名

Oncogene   2017

Joint Work

Research paper (scientific journal)

東北からバイオバンク試料・情報の分譲　東北大学東北メディカル・メガバンク機構

北谷和之

生化学   2017

Single Work

Research paper (scientific journal)

The Tohoku Medical Megabank Project: Design and Mission

Kuriyama S., その他55名および1グループ

J. Epidemiol.   2016

Joint Work

Research paper (scientific journal)

Ceramide limits phosphatidylinositol-3-kinase C2-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid

Kitatani K.,その他10名

Oncogene   2016

Joint Work

Research paper (scientific journal)

Transferrin facilitates the formation of DNA double-strand breaks via transferrin receptor 1: the possible involvement of transferrin in carcinogenesis of high-grade serous ovarian cancer.

Shigeta S.,その他5名

Oncogene.   2016

Joint Work

Research paper (scientific journal)

Network analysis of a comprehensive knowledge repository reveals a dual role for ceramide in Alzheimer’s disease

Mizuno S., その他6名

PLOS ONE   2016

Joint Work

Research paper (scientific journal)

Sphingolipids in inflammation: from bench to bedside.

Kitatani K., Iwabuchi K., Snider A., and Riboni L

Mediat. Inflamm.   2016

Joint Work

Research paper (scientific journal)

Activation of p38 mitogen-activated protein kinase in Gaucher’s disease

Kitatani K.,　その他8名

PLOS ONE   2015

Joint Work

Research paper (scientific journal)

Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide

Yazama H.,その他9名

Int. J. Clin. Oncol.   2015

Joint Work

Research paper (scientific journal)

Role of sphingolipids and metabolizing enzymes in hematological malignancies

Kitatani K., Taniguchi M., and Okazaki T

Mol. Cells   2015

Joint Work

Research paper (scientific journal)

Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer

Mashiko S., その他10名

Cancer Biol. Ther.   2015

Joint Work

Research paper (scientific journal)

Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

Taniguchi M., その他5名

Cell Death Disease   2015

Joint Work

Research paper (scientific journal)

Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway

Perry D.M.その他8名

J. Biol. Chem.   2014

Joint Work

Research paper (scientific journal)

Pharmacological preconditioning of TP-sensitive potassium channel openers on acute urinary retention induced bladder dysfunction in the rat

Ohmasa F., Saito M., Ohiwa H., Tsounapi P., Kitatani K., Dimitriadis F., Kinoshita Y., and Satoh K.

BJU Int   2012

Joint Work

Research paper (scientific journal)

The role of K (ATP) channels on ischemia-reperfusion injury in the rat testis

Tsounapi P., Saito M., Dimitriadis F., Kitatani K., Kinoshita Y., Shomori K., Takenaka A., Satoh K.

Life Sci.   2012

Joint Work

Research paper (scientific journal)

Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decrease responsiveness to signaling by the CXCL12/CXCR4 pathway

Asano S., Kitatani K., Taniguchi M., Hashimoto M., Zama K., Mitsutake S., Igarashi Y., Takeya H., Hayashi A., Umehara H., Kigawa J., and Okazaki T.

Mol. Cell. Biol.   2012

Joint Work

Research paper (scientific journal)

Identification and characterization of PP2C activation by ceramid

Perry. D.M., Kitatani K., Roddy P., El-Osta M., Hannun Y.A.

J. Lipid Res.   2012

Joint Work

Research paper (scientific journal)

Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats

Tsounapi P., Saito M., Kitatani K., Dimitriadis F., Ohmasa F., Shimizu S., Kinoshita Y., Takenaka A., Satoh K.

Eur. J. Pharmacol.   2012

Joint Work

Research paper (scientific journal)

Regulation of autophagy and its associated cell death by sphingolipid rheostat: Reciprocal role in ceramide and sphingosine-1-phosphate in the mTOR pathway

Taniguchi M., Kitatani K., Kondo T., Hashimoto-Nishimura M., Asano S., Hayashi A., Mitsutake S., Igarashi Y., Umehara H., Takeya H., Kigawa J. and Okazaki T.

J. Biol. Chem.   2012

Joint Work

Research paper (scientific journal)

C型慢性肝炎の治療薬開発を通してみた国内外の臨床試験検索サイトの活用方法の模索

平田みよ，浦野義崇，稲葉繁樹,北谷和之,岡崎俊朗，北垣浩志

医薬品医療機器レギュラトリーサイエンス   2012

Joint Work

Research paper (scientific journal)

Phospholipase C and protein kinase C2 mediate insulin-like growth factor 2-dependent sphingosine kinase 1 activation

El-Shewy H.M., Abdel-Samie S.A., Al Qalam A.M., Lee M.H., Kitatani K., Anelli V., Jaffa A.A., Obeid L.M., Luttrell L.M.

Mol. Endocrinol.   2011

Joint Work

Research paper (scientific journal)

Inhibitory effects of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID mice

, Fujiwara K., Kitatani K., Fukushima K., Yazama H., Umehara H., Kikuchi M., Igarashi Y., Kitano H., and Okazaki T.

Int. J. Clin. Oncol.   2011

Joint Work

Research paper (scientific journal)

Selective knockdown of ceramide synthases reveals complex inter-regulation of sphingolipid metabolism

Mullen T.D., Spassieva S., Jenkins R.W., Kitatani K., Bielawski J., Hannun Y.A., and Obeid L.M.

J. Lipid Res.   2011

Joint Work

Research paper (scientific journal)

Regulation of CC ligand 5/rantes by acid sphingomyelinase

Jenkins R.W., Clarke C.J., Canal D., Snider A.J., Gault C.R., Heffernan-Stroud L., Wu B.X., Simbari F., Roddy P., Kitatani K., Obeid L.M., and Hannun Y.A.

J. Biol. Chem.   2011

Joint Work

Research paper (scientific journal)

Isofagomine in vivo effects in a neuropathic Gaucher disease mouse

Sun Y., Ran H., Liou B., Quinn B., Zamzow M., Zhang W., Bielawski J., Kitatani K., Setchell K.D., Hannun Y.A., Witte D.P., Xu Y., and Grabowski G.A.

PLoS One   2011

Joint Work

Research paper (scientific journal)

SMS1-generated sphingomyelin plays an important role in transferring trafficking and cell proliferation

Kitatani K., Abdel Shakor A.B., Taniguchi M., Hashimoto M., Asano S., Hayashi A., Nomura K., Bielawski J., Bielawska A., Watanabe K., Kobayashi T., Igarashi Y., Umehara H., Takeya H., and Okazaki T.

J. Biol. Chem.   2011

Joint Work

Research paper (scientific journal)

酒粕に含まれるスフィンゴ脂質の検出•半定量的評価とその由来の解析

牧江俊雄，黒田祥平,中村剛，今井優樹，森永紀，北谷和之

J. Brew. Soc. Japan.   2011

Joint Work

Research paper (scientific journal)

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation

Jenkins R.W., Canal D., Idkowiak-Baldys J., Simbari F., Roddy P. Perry D.M., Kitatani K., Luberto C., and Hannun Y.A.

J. Biol. Chem.   2010

Joint Work

Research paper (scientific journal)

Neuronopathic Gaucher disease in the mouse: Viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) with CNS glucosylsphingosine and glucosylceramide accumulation

Sun Y., Liou B., Ran H., Skelton M.R., Williams M.T., Vorhees C.V., Kitatani K., Hannun Y.A., Witte D.P., Xu Y., and Grabowski G.A.

Human Mol. Genet.   2010

Joint Work

Research paper (scientific journal)

Specific saposin C deficiency: CNS impairment and acid--glucosidase effects in the mouse

Sun Y., Ran H., Zamzow M., Kitatani K., Skelton M.R., Williams M.T., Vorhees C.V., Witte D.P., Hannun Y.A., and Grabowski G.A.

Human Mol. Genet.   2010

Joint Work

Research paper (scientific journal)

Acid--glucosidase 1 counteracts p38-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.

Kitatani K., Sheldon, K., Anelli, V., Jenkins, R. W., Sun, Y., Grabowski, G. A., Obeid, L. M., and Hannun, Y. A.

J. Biol. Chem.   2009

Joint Work

Research paper (scientific journal)

Involvement of acid--glucosidase 1 in the salvage pathway of ceramide formation.

Kitatani K., Sheldon, K., Anelli, V., Jenkins, R. W., Sun, Y., Grabowski, G. A., Obeid, L. M., and Hannun, Y. A.

J. Biol. Chem.   2009

Joint Work

Research paper (scientific journal)

DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells

Sundra S.,Mani S.K., Kitatani K., Wu. K., Pestell R.G., and Reddy. S.V.

J. Cell. Biochem.   2008

Joint Work

Research paper (scientific journal)

Mechanism of inhibition of sequestration of protein kinase C /ßII by ceramide: roles of ceramide activated protein phosphatases and phosphorylation/dephosphorylation of PKC/II on threonine 638/641.

Kitatani K., Idkowiak-Baldys J., and Hannun Y.A.

J. Biol. Chem.   2007

Joint Work

Research paper (scientific journal)

Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.

Taha T. A., Kitatani K., El-Alwani M., Bielawski J., Hannun Y. A., and Obeid L. M.

FASEB J.   2006

Joint Work

Research paper (scientific journal)

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38

Kitatani K., Idkowiak-Baldys J., Bielawski J., Taha T.A., Jenkins R.W., Senkal C.E., Ogretmen B., Obeid L.M., Hannun Y.A.

J. Biol. Chem.   2006

Joint Work

Research paper (scientific journal)

Dynamic sequestration of the recycling compartment by cPKC.

Idkowiak-Baldys J., Becker K. P., Kitatani K., and Hannun Y. A.

J. Biol. Chem.   2006

Joint Work

Research paper (scientific journal)

Selective inhibition of juxtanuclear translocation of protein kinase C II by a negative feedback mechanism involving ceramide formed from the salvage pathway

Becker K. P., Kitatani K., Idkowiak-Baldys J., Bielawski J., Hannun Y. A.

J. Biol. Chem.   2005

Joint Work

Research paper (scientific journal)

The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate

K. Kitatani, Pettus J. P., Chalfant C.E., Taha T. A., Kawamori T., Bielawski J., Obeid L. M., and Hannun Y.A.

Mol. Pharmacol.   2005

Joint Work

Research paper (scientific journal)

TNF induces the loss of sphingosine kinase-1 by a cathepsin B dependent mechanism.

Taha T. A., Kitatani K., Bielawski J., Cho W., Hannun Y. A. and Obeid L. M.

J. Biol. Chem.   2005

Joint Work

Research paper (scientific journal)

Ceramide-induced enhancement of secretory phospholipase A2 expression via generation of reactive oxygen species in tumor necrosis factor-alpha-stimulated mesangial cells

Kitatani K., Akiba S. and Sato T.

Cell Signal.   2004

Joint Work

Research paper (scientific journal)

Stimulation by de novo-synthesized ceramide of phospholipase A2-dependent cholesterol esterification promoted by uptake of oxidized low-density lipoprotein in macrophages

Kitatani K., Nemoto M., Akiba S. and Sato T.

Cell Signal.   2002

Joint Work

Research paper (scientific journal)

Ceramide accelerates dephosphorylation of extracellular signal-regulated kinases to decrease prostaglandin D2 production in RBL-2H3 cells

Kitatani K., Akiba S., Hayama M. and Sato T.

Arch. Biochem. Biophys.   2001

Joint Work

Research paper (scientific journal)

Secretory phospholipase A2 mediates cooperative prostaglandin generation by growth factor and cytokine independently of preceding cytosolic phospholipase A2 expression in rat gastric epithelial cells

Akiba S., Hatazawa R., Ono K., Kitatani K., Hayama M. and Sato T.

J. Biol. Chem.   2001

Joint Work

Research paper (scientific journal)

Acceleration by ceramide of calcium-dependent translocation of phospholipase A2 from cytosol to membranes in platelets

Kitatani K., Oka T., Murata T., Hayama M., Akiba S. and Sato T.

Arch. Biochem. Biophys.   2000

Joint Work

Research paper (scientific journal)

Role of phospholipase D-derived phosphatidic acid as a substrate for phospholipase A2 in RBL-2H3 cells

Kitatani K., Akiba S. and Sato T.

Biol. Pham. Bull.   2000

Joint Work

Research paper (scientific journal)

Involvement of lipoxygenase pathway in docosapentaenoic acid-induced inhibition of platelet aggregation

Akiba S., Murata, T., Kitatani K. and Sato T.

Biol. Pham. Bull.   2000

Joint Work

Research paper (scientific journal)

Stimulation by ceramide of phospholipase A2 activation through mechanism related to the phospholipase C-initiated signaling pathway in rabbit platelets

Sato T., Kageura T., Hashizume T., Hayama M., Kitatani K. and Akiba S.

J. Biochem (Tokyo)   1999

Joint Work

Research paper (scientific journal)

Ceramide enhances susceptibility of membrane phospholipids to phospholipase A2 through modification of lipid organization in platelet membranes

Hashizume T., Kitatani K., Kageura T., Hayama M., Akiba S. and Sato T.

Biol. Pharm. Bull   1999

Joint Work

Research paper (scientific journal)