Papers - OMOTE Masaaki

Decarboxylative aldol reaction of alpha,alpha-difluoro-beta-keto esters: easy access to difluoroenolate

Atsushi Tarui, Hiroshi Shimomura, Yohei Yasuno, Yukiko Karuo, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote

ACS Omega9 ( 24 ) 26275   2025.06

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

Electrophilic aromatic substitution using fluorinated isoxazolines at C5 position via C-F bond cleavage

Kazuyuki Sato, Tomohiro Kuroki, Haruka Minami, Azusa Sato, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Masaaki Omote

RSC Advances14   39543 - 39549   2024.12

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

Construction of new quaternary carbon center of fluorinated isoxazolines at C5 position via C-F bond cleavage

Kazuyuki Sato, Kazuki Nakano, Takahiro Ueda, Yukine Kitamura, Yuna Tanaka, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Masaaki Omote

Journal of Fluorine Chemistry279   110335   2024.09

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Development of drug discovery platforms using artificial intelligence and cheminformatics

Kentaro Kawai, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Makoto Kataoka, Masaaki Omote

Chem. Pharm. Bull.72 ( 9 ) 794 - 799   2024.09

Joint Work

Research paper (scientific journal)

Authorship: Last author 

DOI

Synthesis of fluoroalkenes and fluoroenynes via cross-coupling reactions using novel multihalogenated vinyl ethers

Yukiko Karuo, Keita Hirata, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote

Beilstein J. Org. Chem.20   2691 - 2703   2024.08

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Rhodium-catalyzed homo-coupling reaction of aryl Grignard reagents and its application for the synthesis of an integrin inhibitor

Kazuyuki Sato, Satoki Teranishi, Atsushi Sakaue, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Hiroyuki Takeda, Tatsuo Kinashi, Masaaki Omote

Beilstein J. Org. Chem.20   1341 - 1347   2024.06

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition

Makoto Kataoka, Takenaka, Shota Fujii, Takato Masada, Keiko Minami, Toshihide Takagi, Masaaki Omote, Kentaro Kawai, Shinji Yamashita

Drug Metabolism and Pharmacokinetics56   101005   2024.04

Joint Work

Research paper (scientific journal)

Pentafluorosulfanyl-substituted biaryl derivatives as MATE-type transporter inhibitors targeting drug-resistant bacteria International coauthorship

Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote

Bioorganic & Medicinal Chemistry99   117606   2024.02

Joint Work

Research paper (scientific journal)

Authorship: Last author 

DOI

Metal-Free Arylation of Pyridine/Quinoline N-Oxides with Indoles International coauthorship

Ryo Tsunokawa, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Takaaki Hosoya, Tomohiro Agou, Kentaro Kawai, Masaaki Omote

European Journal of Organic Chemistry26 ( 47 ) e20230   2023.11

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Reactions using freons and halothane as halofluoroalkyl/halofluoroalkenyl building blocks

Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote

The Chemical Record   e202300029   2023.04

Joint Work

Research paper (scientific journal)

DOI

Rhodium-catalyzed intramolecular reductive aldol-type cyclization: Application for the synthesis of a chiral necic acid lactone

Motoyuki Isoda, Kazuyuki Sato, Kenta Kameda, Kana Wakabayashi, Ryota Sato, Hideki Minami, Yukiko Karuo, Atsushi Tarui, Kentaro Kawai, Masaaki Omote

Beilstein J. Org. Chem.18   1642 - 1648   2022.11

Joint Work

Research paper (scientific journal)

DOI

Simple synthesis of multi-halogenated alkenes from 2-bromo-2-chloro-1,1,1-trifluoroethane (halothane)

Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote

Beilstein J. Org. Chem.18   1567 - 1574   2022.11

Joint Work

Research paper (scientific journal)

DOI

Fluorophenylalkyl-Substituted Cyanoguanidine Derivatives as Bacteria-Selective MATE Transporter Inhibitors for the Treatment of Antibiotic-Resistant Infections

Susumu Shinya, Kentaro Kawai, Naoki Kobayashi, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masato Otsuka, Masaaki Omote

Bioorg. Med. Chem.74   117042   2022.09

Joint Work

Research paper (scientific journal)

DOI

Discovery of benzyloxyphenyl- and phenethylphenyl-imidazole derivatives as a new class of ante–drug type boosters

Kentaro Kawai, Jun Okada, Mizuki Nakae, Toshiki Tsujimura, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Shinji Yamashita, Makoto Kataoka, Masaaki Omote

Bioorganic & Medicinal Chemistry Letters72 ( 15 ) 128868   2022.06

Joint Work

Research paper (scientific journal)

DOI

Synthesis of 2,2-difluoro-2-arylethylamines as fluorinated analogues of octopamine and noradrenaline

Atsushi Tarui, Erika Kamata, Koji Ebisu, Yui Kawai, Ryota Araki, Takeshi Yabe, Yukiko Karuo, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote

Heterocyclic Communications28   26 - 34   2022.03

Joint Work

Research paper (scientific journal)

DOI

LCP: Simple Representation of Docking Poses for Machine Learning: A Case Study on Xanthine Oxidase Inhibitors

Kentaro Kawai, Yoshitaka Asanuma, Toshiki Kato, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Masaaki Omote

Molecular Informatics40   2100245   2021.11

Joint Work

Research paper (scientific journal)

DOI

Importance of the azole moiety of cimetidine derivatives for the inhibition of human multidrug and toxin extrusion transporter 1 (hMATE1)

Susumu Shinya, Kentaro Kawai, Atsushi Tarui, Yukiko Karuo, Kazuyuki Sato, Masaya Matsuda, Kazuyuki Kitatani, Naoki Kobayashi, Takeshi Nabe, Masato Otsuka, Masaaki Omote

Chemical and Pharmaceutical Bulletin69 ( 9 ) 905 - 912   2021.09

Joint Work

Research paper (scientific journal)

DOI

Identification and Synthesis of DDI-6, a Quinolinol Analog Capable of Activating Both Caenorhabditis elegans and Mouse Spermatozoa

Yukiko Karuo, Riona Shiraki, Ayaka Yoshida, Ryo Tsunokawa, Mayuko Nakahara-Yamada, Atsushi Tarui, Kazuyuki Sato, Kentaro Kawai, Masaaki Omote, Hitoshi Nishimura

Chemical and Pharmaceutical Bulletin69 ( 6 ) 557 - 563   2021.06

Joint Work

Research paper (scientific journal)

DOI

Ferulic acid alleviates abnormal behaviors in isolation-reared mice via 5-HT1A receptor partial agonist activity

Ryota Araki, Akira Yasubuchi, Marina Ikegaya, Chihiro Hojo, Hayato Tachioka, Kentaro Kawai, Masaaki Omote, Ayami Kita, Takeshi Yabe

Psychopharmacology238   2147 - 2154   2021.04

Joint Work

Research paper (scientific journal)

Effect of learning dataset for identification of active molecules: a case study of integrin αIIbβ3 inhibitors

Kentaro Kawai, Mami Tomonou, Yume Machida, Yukiko Karuo, Atsushi Tarui, Kazuyuki Sato, Yoshiki Ikeda, Tatsuo Kinashi, Masaaki Omote

Molecular Informatics   202060040   2021.03

Joint Work

Research paper (scientific journal)

DOI