論文 - 小西 元美
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Efficient nose-to-brain delivery of nine residues peptide (JAL-TA9) exhibiting hydrolytic activity against amyloid-β
Yusuke Hatakawa, Akiko Tanaka, Tomoyuki Furubayashi, Hidemasa Katsumi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sakane
European Journal of Pharmaceutics and Biopharmaceutics208 2025年03月
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研究論文（学術雑誌）
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An 11-mer synthetic peptide suppressing aggregation of Aβ25-35 and resolving its aggregated form improves test performance in an Aβ25-35-induced Alzheimer's mouse model
Rina Nakamura, Akira Matsuda, Youichirou Higashi , Yoshihiro Higashi , Motomi Konishi , Motoaki Saito, Toshifumi Akizawa
Biomolecules 14 ( 10 ) 1234 2024年10月
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研究論文（学術雑誌）
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SKGQA, a Peptide Derived from the ANA/BTG3 Protein, Cleaves Amyloid-β with Proteolytic Activity
Yusuke Hatakawa, Rina Nakamura, Toshifumi Akizawa, Motomi Konishi, Akira Matsuda, Tomoyuki Oe, Motoaki Saito, Fumiaki Ito
Biomolecules14 ( 5 ) 586 2024年05月
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研究論文（学術雑誌）
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Five-mer peptides prevent short-term spatial memory defcits in Aβ25-35-induced Alzheimer’s model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form
Rina Nakamura, Motomi Konishi , Youichirou Higashi , Motoaki Saito, Toshifumi Akizawa
Alzheimer’s Research & Therapy 15 83 2023年04月
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研究論文（学術雑誌）
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Structure–Activity Relationship of 5-mer Catalytides, GSGYR and RYGSG
Rina Nakamura; Toshifumi Akizawa; Motomi Konishi
Biomolecules12 ( 12 ) 2022年11月
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研究論文（学術雑誌）
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Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration
Yusuke Hatakawa, Akiko Tanaka, Tomoyuki Furubayashi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sanane,,
Pharmaceutics13 ( 10 ) pharmaceutics13101673 2021年10月
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研究論文（学術雑誌）
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Amyloid-beta cleavage by ANA-TA9, a synthetic peptide from the ANA/BTG3 Box A region
Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshiyasu Sanane, Akiko Tanaka, Akira Matsuda, Motoaki Saito, Toshifumi Akizawa
Alzheimers Dement (N Y)7 ( 1 ) e12146 2021年03月
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研究論文（学術雑誌）
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JAL-TA9 Inhibits Aggregation of hPrP180-192 through the Cleavage Reaction
R. Nakamura, M. Konishi,Y. Sakaguchi, Y. Hatakawa, T. Akizawa,
J Pharm Pharmacol Res4 ( 2 ) 23 - 33 2020年06月
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研究論文（学術雑誌）
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Evaluation of the proteolytic activity of 5-mer peptides in BoxA region of Tob/BTG family proteins against Amyloid-β fragment peptides
Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa
PEPTIDESCIENCE 2019 ９ - 10 2020年02月
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研究論文（学術雑誌）
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Catalytides derived from the Box A region in the ANA/BTG3 protein cleave amyloid-β fragment peptide
Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa
Heliyon5 ( 9 ) 1 - 11 e02454 2019年09月
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研究論文（学術雑誌）
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The Novel Catalytic Peptide, A Synthetic Nona-Peptide (JAL-TA9) Derived from Tob1 Protein, Digests the Amyloid-β Peptide
Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Motoaki Saito, Toshifumi Akizawa
Journal of Royal Science1 ( 2 ) 30 - 35 2019年08月
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研究論文（学術雑誌）
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Comperison of the catalytic activities of 5-mer synthetic peptides derived from Box A region of Tob/BTG family proteins against the amyloid-beta feagment peptides
Rina Nakamura, Motomi Konishi, Youichirou Higashi, Motoaki Saito, Toshifumi Akizawa
Integrative Molecular Medicine6 1 - 4 2019年06月
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研究論文（学術雑誌）
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The discovery of shorter synthetic proteolytic peptides derived from Tob1 protein
Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Yusuke Hatakawa, Toshifumi Akizawa
Peptides116 71 - 77 2019年06月
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研究論文（学術雑誌）
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Effect of Cu2+ on conformational change and aggregation of hPrP180-192 with a V180I mutation of the prion protein
Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Hidenao Toyoda, Toshifumi Akizawa
Biochemical and Biophysical Research Communications 514 ( 3 ) 798 - 802 2019年05月
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研究論文（学術雑誌）
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The effects of Cu2+ on conformational changes of hPrP180-192 dericved from C-terminal region of prion protein
Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Hidenao Toyoda, Toshifumi Akizawa
Biomedical Research on Trace Elements30 ( 1 ) 1 - 8 2019年04月
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研究論文（学術雑誌）
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The Possibility of Creating a Novel Catalytide in PC
Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa
PEPTIDESCIENCE 2018 69 - 69 2019年03月
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研究論文（国際会議プロシーディングス）
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Comparison of proteolytic activity of 5-mer peptides derived from BoxA domain of Tob/BTG family proteins
Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
PEPTIDE SCIENCE 2017 102 - 103 2018年02月
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研究論文（その他学術会議資料等）
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Structure-activity relationship of 5-mer peptides derived from JAL-TA9
Rina Nakamura, Yusuke Hatakawa, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
PEPTIDE SCIENCE 2017 40 - 41 2018年02月
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研究論文（その他学術会議資料等）
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MMP-7 cleaves amyloid β fragment peptides and copper ion inhibits the degradation.
Masanari Taniguchi, Kazuki Matsuura, Aya Kojima, Motomi Konishi, Toshifumi Akizawa.,
BioMetals30 ( 5 ) 797 - 807 2017年05月
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研究論文（学術雑誌）
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THE SYNTHETIC PEPTIDE DERIVED FROM BOXA REGION IN ANA/BTG3 PROTEIN IS THE SECOND CATALYTIDE CLEAVING THE AMYLOID-β PEPTIDE
Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, and Toshifumi Akizawa
Peptide Science 2016 2017年03月
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研究論文（学術雑誌）