論文 - 湯浅　恵造

Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect aku BGL activity

Xiaomei Sun, Yuxin Ye, Naofumi Sakurai, Hang Wang, Koji Kato, Jian Yu, Keizo Yuasa, Akihiko Tsuji, Min Yao

eLife   2023年11月

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研究論文（学術雑誌）

Nonspecific phospholipase C3 of radish has phospholipase D activity towards glycosylinositol phosphoceramide

Rumana Yesmin Hasi, Toshiki Ishikawa, Keigo Sunagawa, Yoshimichi Takai, Hanif Ali, Junji Hayashi, Ryushi Kawakami, Keizo Yuasa, Mutsumi Aihara, Kaori Kanemaru, Hiroyuki Imai, Tamotsu Tanaka

FEBS Letters   2022年12月

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研究論文（学術雑誌）

Natriuretic peptide receptor-C releases and activates guanine nucleotide-exchange factor H1 in a ligand-dependent manner

Mika Nishida, Kenji Miyamoto, Shogo Abe, Maki Shimada, Yuki Shimizu, Akihiko Tsuji, Keizo Yuasa

Biochemical and Biophysical Research Communications   2021年05月

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研究論文（学術雑誌）

Secretory production of a camelid single-domain antibody (VHH, nanobody) by the Serratia marcescens Lip system in Escherichia coli

Tomonori Asada, Daichi Takagi, Miyu Nakai, Shogo Abe, Keizo Yuasa

Biochemical and Biophysical Research Communications   2021年04月

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研究論文（学術雑誌）

Citrus sudachi Peel Extract Suppresses Cell Proliferation and Promotes the Differentiation of Keratinocytes through Inhibition of the EGFR-ERK Signaling Pathway

Shogo Abe, Misako Ueno, Mami Nishitani, Tetsuya Akamatsu, Takumi Sato, Marie Shimoda, Hiroki Kanaoka, Yoshitaka Nii, Hiroko Yamasaki, Keizo Yuasa

Biomolecules   2020年10月

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研究論文（学術雑誌）

Crystallographic analysis of Eisenia hydrolysis-enhancing protein using a long wavelength for native-SAD phasing

Xiaomei Sun, Yuxin Ye, Naofumi Sakurai, Koji Kato, Keizo Yuasa, Akihiko Tsuji, Min Yao

Acta Crystallographica Section F Structural Biology Communications   2020年01月

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研究論文（学術雑誌）

Sudachitin, a polymethoxyflavone from Citrus sudachi, induces apoptosis via the regulation of MAPK pathways in human keratinocyte HaCaT cells

Shogo Abe, Keizo Yuasa

Biochemical and Biophysical Research Communications   2019年11月

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研究論文（学術雑誌）

Identification and enzymatic characterization of clip domain serine protease in the digestive fluid of the sea hare, Aplysia kurodai

Akihiko Tsuji, Keizo Yuasa

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology   2019年11月

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研究論文（学術雑誌）

Citrus peel polymethoxyflavones, sudachitin and nobiletin, induce distinct cellular responses in human keratinocyte HaCaT cells

Shogo Abe, Saki Hirose, Mami Nishitani, Ichiro Yoshida, Masao Tsukayama, Akihiko Tsuji, Keizo Yuasa

Bioscience, Biotechnology, and Biochemistry   2018年12月

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研究論文（学術雑誌）

Cellulose-binding activity of a 21-kDa endo-ß-1,4-glucanase lacking cellulose-binding domain and its synergy with other cellulases in the digestive fluid of Aplysia kurodai

Akihiko Tsuji, Keizo Yuasa, Chikako Asada

PLoS One   2018年11月

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研究論文（学術雑誌）

Intracellular localization and binding partners of death associated protein kinase-related apoptosis-inducing protein kinase 1

Yuna Oue, Sara Murakami, Kinuka Isshiki, Akihiko Tsuji, Keizo Yuasa

Biochemical and Biophysical Research Communications   2018年02月

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研究論文（学術雑誌）

Change in plasma membrane potential of rat thymocytes by tert-butylhydroquinone, a food additive: Possible risk on lymphocytes

Maki Takeda, Keisuke Oyama, Norio Kamemura, Kaori Kanemaru, Keizo Yuasa, Kumio Yokoigawa, Yasuo Oyama

Food and Chemical Toxicology   2017年11月

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研究論文（学術雑誌）

PCTK3/CDK18 regulates cell migration and adhesion by negatively modulating FAK activity

Shinya Matsuda, Kohei Kawamoto, Kenji Miyamoto, Akihiko Tsuji, Keizo Yuasa

Scientific Reports   2017年03月

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研究論文（学術雑誌）

Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells

Ichiro Yoshida, Chihiro Ito, Shinya Matsuda, Akihiko Tsuj, Noriyuki Yanaka, Keizo Yuasa

Bioscience, Biotechnology, and Biochemistry   2017年03月

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研究論文（学術雑誌）

Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells

Norio Kamemura, Sara Murakami, Hiroaki Komatsu, Masahiro Sawanoi, Kenji Miyamoto, Kazumi Ishidoh, Koji Kishimoto, Akihiko Tsuji, Keizo Yuasa

Biochemical and Biophysical Research Communications   2017年01月

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研究論文（学術雑誌）

Identification and characterization of a 25 kDa protein that is indispensable for the efficient saccharification of Eisenia bicyclis in the digestive fluid of Aplysia kurodai

Akihiko Tsuji, Shuji Kuwamura, Akihiro Shirai, Keizo Yuasa

PLoS ONE   2017年01月

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研究論文（学術雑誌）

Structural basis of cyclic nucleotide selectivity in cGMP-dependent protein kinase II

James C Campbell, Jeong Joo Kim, Kevin Y Li, Gilbert Y Huang, Albert S Reger, Shinya Matsuda, Banumathi Sankaran, Todd M Link, Keizo Yuasa, John E Ladbury, Darren E Casteel, Choel Kim

The Journal of Biological Chemistry   2016年03月

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研究論文（学術雑誌）

Death-associated protein kinase 2 mediates nocodazole-induced apoptosis through interaction with tubulin

Kinuka Isshiki, Taishi Hirase, Shinya Matsuda, Kenji Miyamoto, Akihiko Tsuji, Keizo Yuasa

Biochemical and Biophysical Research Communications   2015年12月

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研究論文（学術雑誌）

NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing

Yuki Yoshikatsu, Yo-ichi Ishida, Haruka Sudo, Keizo Yuasa, Akihiko Tsuji, Masami Nagahama

Biochemical and Biophysical Research Communications   2015年08月

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研究論文（学術雑誌）

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins

Keizo Yuasa, Reina Ota, Shinya Matsuda, Kinuka Isshiki, Masahiro Inoue, Akihiko Tsuji

Biochemical and Biophysical Research Communications   2015年08月

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研究論文（学術雑誌）

Estrogen stimuli promote osteoblastic differentiation via the subtilisin-like proprotein convertase PACE4 in MC3T3-E1 cells

Hyejin Kim, Atsushi Tabata, Toshifumi Tomoyasu, Tomomi Ueno, Shigeto Uchiyama, Keizo Yuasa, Akihiko Tsuji, Hideaki Nagamune

Journal of Bone and Mineral Metabolism   2015年01月

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研究論文（学術雑誌）

Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions

Albert S Reger, Matthew P Yang, Shizuyo Koide-Yoshida, Elaine Guo, Shrenik Mehta, Keizo Yuasa, Alan Liu, Darren E Casteel, Choel Kim

The Journal of Biological Chemistry   2014年09月

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研究論文（学術雑誌）

PCTAIRE kinase 3/cyclin dependent kinase 18 is activated through association with cyclin A and/or phosphorylation by protein kinase A

Shinya Matsuda, Kyohei Kominato, Shizuyo Koide-Yoshida, Kenji Miyamoto, Kinuka Isshiki, Akihiko Tsuji, Keizo Yuasa

The Journal of Biological Chemistry   2014年06月

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研究論文（学術雑誌）

Possible role of inter-domain salt bridges in oligopeptidase B from Trypanosoma brucei: critical role of Glu172 of non-catalytic β-propeller domain in catalytic activity and Glu490 of catalytic domain in stability of OPB

Junki Fukumoto, Nor Ismaliza Mohd Ismail, Masaki Kubo, Keita Kinoshita, Masahiro Inoue, Keizo Yuasa, Makoto Nishimoto, Hitoshi Matsuki, Akihiko Tsuji

The Journal of Biochemistry   2013年11月

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研究論文（学術雑誌）

Comprehensive enzymatic analysis of the cellulolytic system in digestive fluid of the sea hare Aplysia kurodai. Efficient glucose release from sea lettuce by synergistic action of 45 kDa endoglucanase and 210 kDa ß-glucosidase

Akihiko Tsuji, Keiko Tominaga, Nami Nishiyama, Keizo Yuasa

PLoS ONE   2013年06月

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研究論文（学術雑誌）

Engineering of α1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis

Koichiro Hada, Kinuka Isshiki, Shinya Matsuda, Keizo Yuasa, Akihiko Tsuji

Protein Engineering, Design & Selection   2013年02月

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研究論文（学術雑誌）

Enzymatic characterization of germination-specific cysteine protease-1 expressed transiently in cotyledons during the early phase of germination

Akihiko Tsuji, Kana Tsukamoto, Keiko Iwamoto, Yuka Ito, Keizo Yuasa

The Journal of Biochemistry   2013年01月

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研究論文（学術雑誌）

Subtilisin-like proprotein convertase paired basic amino acid-cleaving enzyme 4 is required for chondrogenic differentiation in ATDC5 cells

Keizo Yuasa, Go Futamatsu, Tsuyoshi Kawano, Masaki Muroshita, Yoko Kageyama, Hiromi Taichi, Hiroshi Ishikawa, Masami Nagahama, Yoshiko Matsuda, Akihiko Tsuji

The FEBS Journal   2012年11月

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研究論文（学術雑誌）

Purification and characterization of cellulase from North Pacific krill (Euphausia pacifica). Analysis of cleavage specificity of the enzyme.

Akihiko Tsuji, Shiori Sato, Ayumi Kondo, Keiko Tominaga, Keizo Yuasa

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology   2012年11月

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研究論文（学術雑誌）

Structure of β-1,4-mannanase from the common sea hare Aplysia kurodai at 1.05 Å resolution

Kimihiko Mizutani, Sae Tsuchiya, Mayuko Toyoda, Yuko Nanbu, Keiko Tominaga, Keizo Yuasa, Nobuyuki Takahashi, Akihiko Tsuji, Bunzo Mikami

Acta Crystallographica. Section F, Structural Biology and Crystallization Communications   2012年10月

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研究論文（学術雑誌）

cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2

Kinuka Isshiki, Shinya Matsuda, Akihiko Tsuji, Keizo Yuasa

Biochemical and Biophysical Research Communications   2012年06月

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研究論文（学術雑誌）

cGMP-dependent protein kinase I is involved in neurite outgrowth via a Rho effector, rhotekin, in Neuro2A neuroblastoma cells

Keizo Yuasa, Takeshi Nagame, Makoto Dohi, Yayoi Yanagita, Shin Yamagami, Masami Nagahama, Akihiko Tsuji

Biochemical and Biophysical Research Communications   2012年05月

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研究論文（学術雑誌）

Sudachitin, a polymethoxyflavone from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells

Keizo Yuasa, Kaori Tada, Genki Harita, Tomomi Fujimoto, Masao Tsukayama, Akihiko Tsuji

Bioscience, Biotechnology, and Biochemistry   2012年03月

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研究論文（学術雑誌）

Identification of a plant aminopeptidase with preference for aromatic amino acid residues as a novel member of the prolyl oligopeptidase family of serine proteases

Akihiko Tsuji, Yoshinori Fujisawa, Takeru Mino, Keizo Yuasa

The Journal of Biochemistry   2011年11月

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研究論文（学術雑誌）

Functional regulation of transient receptor potential canonical 7 by cGMP-dependent protein kinase Iα

Keizo Yuasa, Taito Matsuda, Akihiko Tsuji

Cellular Signalling   2011年07月

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研究論文（学術雑誌）

A critical role for highly conserved Glu610 residue of oligopeptidase B from Tryoanosoma brucei in thermal stability

Nor Ismaliza Mohd Ismail, Tsuyoshi Yuasa, Keizo Yuasa, Yuko Nambu, Makoto Nisimoto, Masaki Goto, Hitoshi Matsuki, Masahiro Inoue, Masami Nagahama, Akihiko Tsuji

The Journal of Biochemistry   2010年02月

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研究論文（学術雑誌）

Transcriptional regulation of cGMP-dependent protein kinase II (cGK-II) in chondrocytes

Keizo Yuasa, Shotaro Uehara, Masami Nagahama, Akihiko Tsuji

Bioscience, Biotechnology, and Biochemistry   2010年01月

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研究論文（学術雑誌）

Subtilisin-like proprotein convertase PACE4 is required for skeletal muscle differentiation

Keizo Yuasa, Tetsuya Masuda, Chihiro Yoshikawa, Masami Nagahama, Yoshiko Matsuda, Akihiko Tsuji

The Journal of Biochemistry   2009年09月

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研究論文（学術雑誌）

UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation

Masami Nagahama, Machi Ohnishi, Yumiko Kawate, Takayuki Matsui, Hitomi Miyake, Keizo Yuasa, Katsuko Tani, Mitsuo Tagaya, Akihiko Tsuji

Biochemical and Biophysical Research Communications   2009年05月

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研究論文（学術雑誌）

Transcriptional regulation of fibrillin-2 gene by E2F family members in chondrocyte differentiation

Takuya Yanagino, Keizo Yuasa, Masami Nagahama, Yoshiko Matsuda, Akihiko Tsuji

Journal of Cellular Biochemistry   2009年03月

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研究論文（学術雑誌）

Isolation and biochemical characterization of two forms of RD21 from cotyledons of daikon radish (Raphanus sativus)

Yayoi Kikuchi, Hiroko Saika, Keizo Yuasa, Masami Nagahama, Akihiko Tsuji

The Journal of Biochemistry   2008年12月

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研究論文（学術雑誌）

Purification and characterization of cathepsin B-like cysteine protease from cotyledons of daikon radish, Raphanus sativus

Akihiko Tsuji, Yayoi Kikuchi, Kentaro Ogawa, Hiroko Saika, Keizo Yuasa, Masami Nagahama

The FEBS Journal   2008年11月

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研究論文（学術雑誌）

Trafficking of cGMP-dependent protein kinase II via interaction with Rab11

Keizo Yuasa, Shin Yamagami, Masami Nagahama, Akihiko Tsuji

Biochemical and Biophysical Research Communications   2008年09月

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研究論文（学術雑誌）

Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: Possible role of E2F-mediated upregulation of PACE4 in tumor progression

Keizo Yuasa, Kaori Suzue, Masami Nagahama, Yoshiko Matsuda, Akihiko Tsuji

Gene   2007年11月

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研究論文（学術雑誌）

Engineering of α1-antitrypsin variants selective for subtilisin-like proprotein convertases PACE4 and PC6: Importance of the P2' residue in stable complex formation of the serpin with proprotein convertase

Akihiko Tsuji, Hiroki Kanie, Hirotaka Makise, Keizo Yuasa, Masami Nagahama, Yoshiko Matsuda

Protein Engineering, Design & Selection   2007年04月

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研究論文（学術雑誌）

A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4

Akihiko Tsuji, Yayoi Kikuchi, Yukimi Sato, Shizuyo Koide, Keizo Yuasa, Masami Nagahama, Yoshiko Matsuda

The Biochemical Journal   2006年05月

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研究論文（学術雑誌）

Protamine: a unique and patent inhibitor of oligopeptidase B

Akihiko Tsuji, Tadashi Yoshimoto, Keizo Yuasa, Yoshiko Matsuda

Journal of Peptide Science   2006年01月

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研究論文（学術雑誌）

PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum

Keizo Yuasa, Fumika Mi-Ichi, Tamaki Kobayashi, Masaya Yamanouchi, Jun Kotera, Kiyoshi Kita, Kenji Omori

The Biochemical Journal   2005年11月

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研究論文（学術雑誌）

Identification of oligopeptidase B in higher plants. Purification and characterization of oligopeptidase B from quiescent wheat embryo, Triticum aestivum.

Akihiko Tsuji, Keizo Yuasa, Yoshiko Matsuda

The Journal of Biochemistry   2004年11月

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研究論文（学術雑誌）

Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain

Tamaki Kobayashi, Michiko Gamanuma, Takashi Sasaki, Yoko Yamashita, Keizo Yuasa, Jun Kotera, Kenji Omori

Gene   2003年11月

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研究論文（学術雑誌）

Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans

Michiko Gamanuma, Keizo Yuasa, Takashi Sasaki, Naoki Sakurai, Jun Kotera, Kenji Omori

Cellular Signalling   2003年06月

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研究論文（学術雑誌）

Enzymological and pharmacological profile of T-0156, a potent and selective phosphodiesterase type 5 inhibitor

Hideki Mochida, Michino Takagi, Hirotaka Inoue, Tsunehisa Noto, Koji Yano, Kotomi Fujishige, Takashi Sasaki, Keizo Yuasa, Jun Kotera, Kenji Omori, Kohei Kikkawa

European Journal of Pharmacology   2002年12月

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研究論文（学術雑誌）

Identification of rat cyclic nucleotide phosphodiesterase 11A (PDE11A). Comparison of rat and human PDE11A splicing variants.

Keizo Yuasa, Takanori Ohgaru, Masatoshi Asahina, Kenji Omori

European Journal of Biochemistry   2001年08月

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研究論文（学術雑誌）

Genomic organization of the human phosphodiesterase PDE11A gene. Evolutionary relatedness with other PDEs containing GAF domains.

Keizo Yuasa, Yutaka Kanoh, Katsuzumi Okumura, Kenji Omori

European Journal of Biochemistry   2001年01月

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研究論文（学術雑誌）

Characterization and effects of methyl-2- (4-aminophenyl)-1,2- dihydro-1-oxo-7- (2-pyridinylmethoxy)-4- (3,4,5-trimethoxyphenyl)-3- isoquinoline carboxylate sulfate (T-1032), a novel potent inhibitor of cGMP- binding cGMP-specific phosphodiesterase (PDE5)

Jun Kotera, Kotomi Fujishige, Hideo Michibata, Keizo Yuasa, Akira Kubo, Yoshinori Nakamura, Kenji Omori

Biochemical Pharmacology   2000年11月

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研究論文（学術雑誌）

Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression

Keizo Yuasa, Jun Kotera, Kotomi Fujishige, Hideo Michibata, Takashi Sasaki, Kenji Omori

The Journal of Biological Chemistry   2000年10月

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研究論文（学術雑誌）

The human phosphodiesterase PDE10A gene. Genomic organization and evolutionary relatedness with other PDEs containing GAF domains.

Kotomi Fujishige, Jun Kotera, Keizo Yuasa, Kenji Omori

European Journal of Biochemistry   2000年10月

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研究論文（学術雑誌）

Identification of human PDE7B, a cAMP-specific phosphodiesterase

Takashi Sasaki, Jun Kotera, Keizo Yuasa, Kenji Omori

Biochemical and Biophysical Research Communications   2000年05月

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研究論文（学術雑誌）

Binding and phosphorylation of a novel male germ cell-specific cGMP-dependent protein kinase-anchoring protein by cGMP-dependent protein kinase Iα

Keizo Yuasa, Kenji Omori, Noriyuki Yanaka

The Journal of Biological Chemistry   2000年02月

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研究論文（学術雑誌）

Identification of a conserved residue responsible for the autoinhibition of cGMP-dependent protein kinase Iα and β

Keizo Yuasa, Hideo Michibata, Kenji Omori, Noriyuki Yanaka

FEBS Letters   2000年01月

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研究論文（学術雑誌）

Specific domain of cGMP-dependent protein kinase Iβ but not Iα functions as a transcriptional activator in yeast

Keizo Yuasa, Kenji Omori, Noriyuki Yanaka

IUBMB Life   2000年01月

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研究論文（学術雑誌）

A novel interaction of cGMP-dependent protein kinase I with troponin T

Keizo Yuasa, Hideo Michibata, Kenji Omori, Noriyuki Yanaka

The Journal of Biological Chemistry   1999年12月

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研究論文（学術雑誌）

Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP

Jun Kotera, Kotomi Fujishige, Keizo Yuasa, Kenji Omori

Biochemical and Biophysical Research Communications   1999年08月

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研究論文（学術雑誌）

Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)

Kotomi Fujishige, Jun Kotera, Hideo Michibata, Keizo Yuasa, Shin-ichiro Takebayashi, Katsuzumi Okumura, Kenji Omori

The Journal of Biological Chemistry   1999年06月

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研究論文（学術雑誌）