Papers - SAKUMA Shinji
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Validation of the absorption-enhancing ability of oligoarginines grafted onto a backbone of hyaluronic acid through animal studies from rodents to primates
Haruya Yagi, Takumi Tomono, Koji Abe, Yasuhiro Tsutsumi, Muneyoshi Makabe, Hiromi Mitsuhashi, Takayuki Kimura, Hideo Kobayashi, Kohei Miyata, Koichi Shigeno, Shinji Sakuma
Mol. Pharmaceutics21 ( 7 ) 3485 - 3501 2024.05
Joint Work
Research paper (scientific journal)
Authorship: Corresponding author
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Mucosal absorption of antibody drugs enhanced by cell-penetrating peptides anchored to a platform of polysaccharides
Takumi Tomono, Haruya Yagi, Ryoji Igi, Akihiro Tabaru, Koichi Fujimoto, Kaho Enomoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma
Int. J. Pharm.647 123499 2023.10
Joint Work
Research paper (scientific journal)
Authorship: Corresponding author
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Performance of cell-penetrating peptides anchored to polysaccharide platforms applied via various mucosal routes as an absorption enhancer
Haruya Yagi, Takumi Tomono, Yuma Handa, Natsuki Saito, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma
Mol. Pharmaceutics20 ( 1 ) 303 - 313 2022.12
Joint Work
Research paper (scientific journal)
Authorship: Corresponding author
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Acquisition of absorption-enhancing abilities of cationic oligopeptides with short chain arginine residues through conjugation to hyaluronic acid
Takumi Tomono, Haruya Yagi, Saki Kanemoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma
Int. J. Pharm.616 121519 2022.01
Joint Work
Research paper (scientific journal)
Authorship: Corresponding author
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Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine
Takumi Tomono, Haruya Yagi, Masami Ukawa, Seiya Ishizaki, Takahiro Miwa, Mao Nonomura, Ryoji Igi, Hironori Kumagai, Kohei Miyata, Etsuo Tobita, Hideo Kobayashi, Shinji Sakuma
Eur. J. Pharm. Biopharm.154 186 - 194 2020.07
Joint Work
Research paper (scientific journal)
Authorship: Corresponding author
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Biocompatible polymers modified with D-octaarginine as an absorption enhancer for nasal peptide delivery
Kohei Miyata, Masami Ukawa, Kohta Mohri, Kozue Fujii, Mako Yamada, Sohei Tanishita, Satoshi Higashitarumi, Seiya Ishizaki, Hironori Kumagai, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Koichi Shigeno, Etsuo Tobita, Hideo Kobayashi, Shinji Sakuma
Bioconjugate Chem.29 1748 - 1755 2018.04
Joint Work
Research paper (scientific journal)
Authorship: Corresponding author
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Oligoarginine-linked polymers as a new class of penetration enhancers.
Shinji Sakuma, Masaya Suita, Yoshie Masaoka, Makoto Kataoka, Noriko Nakajima, Norihiro Shinkai, Hitoshi Yamauchi, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Ryoji Kimura, Shinji Yamashita
J. Control. Release148 ( 2 ) 187 - 196 2010.12
Joint Work
Research paper (scientific journal)
Authorship: Lead author Corresponding author
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Impact of Composition of Lipid-Based Formulations on First-Pass Drug Metabolism after Oral Administration
Yusuke Tanaka, Rikuto Fukaishi, Daiki Okamoto, Takanori Kurakazu, Tokio Nakai, Haruya Yagi, Shinji Sakuma
Mol. Pharmaceutics22 ( 4 ) 2098 - 2107 2025.03
Joint Work
Research paper (scientific journal)
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The Improved Antigen Uptake and Presentation of Dendritic Cells Using Cell-Penetrating D-octaarginine-Linked PNVA-co-AA as a Novel Dendritic Cell-Based Vaccine
Yuri Fujioka, Hideto Ueki, Ruhan, Akari Sasajima, Takumi Tomono, Masami Ukawa, Haruya Yagi, Shinji Sakuma, Koichi Kitagawa, Toshiro Shirakawa
Int. J. Mol. Sci.25 5997 2024.05
Joint Work
Research paper (scientific journal)
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In vitro digestion–in situ absorption setup employing a physiologically relevant value of the membrane surface area/volume ratio for evaluating performance of lipid-based formulations: A comparative study with an in vitro digestion–permeation model
Yusuke Tanaka, Hinata Arai, Aya Hidaka, Saki Noda, Ko Imai, Fumiya Tsujisawa, Haruya Yagi, Shinji Sakuma
Mol. Pharmaceutics21 ( 7 ) 3459 - 3470 2024.05
Joint Work
Research paper (scientific journal)
Authorship: Last author
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Evaluation of a D-octaarginine-linked polymer as a transfection tool for transient and stable transgene expression in human and murine cell lines
Saki Sakuma, Mariko Okamoto, Nao Matsushita, Masami Ukawa, Takumi Tomono, Keiko Kawamoto, Teruo Ikeda, Shinji Sakuma
J. Vet. Med. Sci.84 ( 4 ) 484 - 493 2022.02
Joint Work
Research paper (scientific journal)
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Mechanism on antigen delivery under mucosal vaccination using cell-penetrating peptides immobilized at multiple points on polymeric platforms
Masami Ukawa, Rikito Endo, Haruya Yagi, Takumi Tomono, Kohei Miyata, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma
Int. J. Pharm.613 121376 2021.12
Joint Work
Research paper (scientific journal)
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Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells
Kohta Mohri, Emi Hayashi, Manato Nishino, Nao Matsushita, Sohei Tanishita, Makiya Nishikawa, Shinji Sakuma
J. Drug Targeting29 ( 2 ) 217 - 224 2020.10
Joint Work
Research paper (scientific journal)
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Cross-protective abilities of hyaluronic acid modified with tetraglycine-L-octaarginine as a mucosal adjuvant against infection with heterologous influenza viruses
Sohei Tanishita, Masami Ukawa, Takumi Tomono, Yuki Yoshida, Takumi Tsujioka, Kohei Miyata, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma
Bioconjugate Chem.30 ( 12 ) 3028 - 3037 2019.11
Joint Work
Research paper (scientific journal)
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Biodegradable hyaluronic acid modified with tetraglycine-L-octaarginine as a safe adjuvant for mucosal vaccination
Masami Ukawa, Sohei Tanishita, Haruya Yagi, Yuki Yoshida, Takumi Tomono, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma
Mol. Pharmceutics16 1105 - 1118 2019.02
Joint Work
Research paper (scientific journal)
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Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues
Hironori Kumagai, Kosuke Yamada, Kanako Nakai, Tokio Kitamura, Kohta Mohri, Masami Ukawa, Takumi Tomono, Takaaki Eguchi, Testuya Yoshizaki, Takumi Fukuchi, Takuya Yoshino, Minoru Matsuura, Etsuo Tobita, Wellington Pham, Hiroshi Nakase, Shinji Sakuma
Eur. J. Pharm. Biopharm.136 29 - 37 2019.01
Joint Work
Research paper (scientific journal)
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Specific molecular recognition as a strategy to delineate tumor margin using topically applied fluorescence embedded nanoparticles
Shawn Barton, Bo Li, Michael Siuta, Vaibhav A Janve, Jessica Song, Clinton M. Holt, Takumi Tomono, Masami Ukawa, Hironori Kumagai, Etsuo Tobita, Kevin Wilson, Shinji Sakuma, Wellington Pham
Prec. Nanomed.1 ( 3 ) 194 - 207 2018.10
Joint Work
Research paper (scientific journal)
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Phase separation of supersaturated solution created from amorphous solid dispersions: Relevance to oral absorption
Kohsaku Kawakami, Keiko Sato, Mayuko Fukushima, Aoi Miyazaki, Yuko Yamamura, Shinji Sakuma
Eur. J. Pharm. Biopharm.132 146 - 156 2018.09
Joint Work
Research paper (scientific journal)
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Effects of the chemical structures of oligoarginines conjugated to biocompatible polymers as a mucosal adjuvant on antibody induction in nasal cavities
Kohta Mohri, Kohei Miyata, Tomomi Egawa, Sohei Tanishita, Rikito Endo, Haruya Yagi, Masami Ukawa, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma
Chem. Pharm. Bull.66 ( 4 ) 375 - 381 2018.04
Joint Work
Research paper (scientific journal)
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Elucidation of the mechanism of increased activity of immunostimulatory DNA by the formation of polypod-like structure
Kohta Mohri, Kengo Nagata, Shozo Ohtsuki, Shiori Toyama, Mao Nonomura, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa, Shinji Sakuma
Pharm. Res.34 ( 11 ) 2362 - 2370 2017.08
Joint Work
Research paper (scientific journal)
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Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer
Hiroshi Nakase, Shinji Sakuma, Kohta Mohri, John Gore, Wellington Pham, 他11名
Int. J. Nanomedicine12 1747 - 1755 2017.03
Joint Work
Research paper (scientific journal)
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Physicochemical properties of solid phospholipid particles as a drug delivery platform for improving oral absorption of poorly soluble drugs
Kohsaku Kawakami, Aoi Miyazaki, Yuko Yamamura, Kohta Mohri, Shinji Sakuma, 他2名
Pharm. Res.34 ( 1 ) 208 - 216 2016.11
Joint Work
Research paper (scientific journal)
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Quantitative analysis of pharmacokinetic profiles of verapamil and drug-drug interactions induced by a CYP inhibitor using a stable isotope-labeled compound
Makoto Kataoka, Chie Kojima, Haruki Higashino, Shinji Sakuma, Shinji Yamashita, 他4名
Drug Metab. Pharmacokinet.31 ( 6 ) 405 - 410 2016.08
Joint Work
Research paper (scientific journal)
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Demonstration of D-octaarginine-linked polymers as promising adjuvants for mucosal vaccination through influenza virus challenge
Kohei Miyata, Kohta Mohri, Tomomi Egawa, Masanori Baba, Shinji Sakuma, 他7名
Bioconjug. Chem.27 ( 8 ) 1865 - 1871 2016.07
Joint Work
Research paper (scientific journal)
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Effects of gastric pH on oral drug absorption: In vitro assessment using a dissolution/permeation system reflecting the gastric dissolution process
Makoto Kataoka, Miho Fukahori, 他5名
Eur. J. Pharm. Biopharm.101 103 - 111 2016.02
Joint Work
Research paper (scientific journal)
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Evaluation of dose-dependent oral absorption of a newly developed drug candidate: in vitro-in vivo correlation
Koji Yano, Makoto Kataoka, 他7名
J. Drug Deliv. Sci. Technol.31 160 - 166 2016.01
Joint Work
Research paper (scientific journal)
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Potential of D-octaarginine-linked polymers as an in vitro transfection tool of biomolecules
Kohta Mohri, Naoki Morimoto, 他12名
Bioconjug. Chem.26 1782 - 1790 2015.08
Joint Work
Research paper (scientific journal)
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Enhanced boosting of oral absorption of lopinavir through electrospray co-encapsulation with ritonavir
Shinji Sakuma, Satoshi Matsumoto, 他5名
J. Pharm. Sci.104 ( 9 ) 2977 - 2985 2015.05
Joint Work
Research paper (scientific journal)
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Impact of luminal fluid volume on the drug absorption after oral administration: analysis based on in vivo drug concentration-time profile in the gastrointestinal tract
Yusuke Tanaka, Takanori Goto, 他3名
J. Pharm. Sci.in press in press 2015.03
Joint Work
Research paper (scientific journal)
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Toxicity studies of coumarin 6-encapsulated polystyrene nanospheres conjugated with peanut agglutinin and poly(N-vinylacetamide) as a colonoscopic imaging agent in rats
Shinji Sakuma, Hironori Kumagai, 他10名
Nanomedicine: NBM.11 ( 5 ) 1227 - 1236 2015.02
Research paper (scientific journal)
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Cross-reactivity of immunoglobulin A secreted on the nasal mucosa in mice nasally inoculated with inactivated H1N1 influenza A viruses in the presence of D-octaarginine-linked polymers
Shinji Sakuma, Naoki Morimoto, 他14名
Eur. J. Pharm. Biopharm.92 56 - 64 2015.02
Joint Work
Research paper (scientific journal)
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A new in vitro system for evaluation of passive intestinal drug absorption: establishment of a double artificial membrane permeation assay
Makoto Kataoka, Saki Tsuneishi, 他4名
Eur. J. Pharm. Biopharm.88 ( 3 ) 840 - 846 2014.10
Joint Work
Research paper (scientific journal)
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Fluorescence-based endoscopic imaging of Thomsen-Friedenreich antigen to improve early detection of colorectal cancer
Shinji Sakuma, James Y. H. Yu, 他18名
Int. J. Cancer136 ( 5 ) 1095 - 1103 2014.07
Joint Work
Research paper (scientific journal)
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Specificity of lectin-immobilized fluorescent nanospheres for colorectal tumors in a mouse model which better resembles the clinical disease
Tokio Kitamura, Shinji Sakuma, 他13名
Contrast Media Mol. Imaging10 ( 2 ) 135 - 143 2014.06
Joint Work
Research paper (scientific journal)
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In vitro-in vivo correlation in the effect of supersaturation on intestinal absorption of BCS class 2 drugs
Haruki Higashino, Tsubasa Hasegawa, et al., 他6名
Mol. Pharmaceutics11 ( 3 ) 746 - 754 2014.02
Joint Work
Research paper (scientific journal)
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Cyclodextrins improve oral absorption of a novel factor Xa inhibitor by interfering with interaction between the drug and bile acids in rats
Yoshimine Fujii, Masayuki Takahashi et al., 他4名
J. Pharm. Pharmacol.65 ( 11 ) 1598 - 1606 2013.09
Joint Work
Research paper (scientific journal)
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Assessment of absorption potential of poorly water-soluble drugs by using the dissolution/permeation system
Makoto Kataoka, Koji Yano et al., 他4人
Eur. J. Pharm. Biopharm.85 ( 3B ) 1317?1324 2013.06
Joint Work
Research paper (scientific journal)
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Preparation of fenofibrate solid dispersion using electrospray deposition and improvement in oral absorption by instantaneous post-heating of the formulation
Kohsaku Kawakami, Shaoling Zhang, et al. 他9名
Int. J. Pharm.450 ( 1月2日 ) 123 - 128 2013.06
Joint Work
Research paper (scientific journal)
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オリゴアルギニン固定化高分子を用いた低膜透過性分子の細胞膜透過促進
日渡謙一郎（全2名）
Drug Delivery System28 ( 2 ) 109 - 118 2013.03
Joint Work
Research paper (scientific journal)
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Measurement of drug concentration in the stomach after intragastric administration of drug solution to healthy volunteers
Shinji Yamashita, Makoto Kataoka, et al.（全11名）
Pharm. Res.30 ( 4 ) 951 - 958 2012.11
Joint Work
Research paper (scientific journal)
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Multifunctional nanobeacon for imaging Thomsen-Friedenreich antigen-associated colorectal cancer
Hironori Kumagai, Wellington Pham（全12名）
Int. J. Cancer132 ( 9 ) 2107 - 2117 2012.10
Joint Work
Research paper (scientific journal)
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Cell-penetrating peptide-linked polymers as carriers for mucosal vaccine delivery
Masaya Suita, Saki Inoue, et al.（全16名）
Mol. Pharmaceutics9 ( 10 ) 2933 - 2941 2012.09
Joint Work
Research paper (scientific journal)
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精神疾患治療に用いられる内服薬へのControlled Release Technologyの導入とその意義
加藤正樹，木村敏史，藤田信明（全4名）
臨床精神薬理15 ( 8 ) 1387 - 1402 2012.08
Joint Work
Research paper (scientific journal)
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Establishment of MDCKII cell monolayer with metabolic activity by CYP3A4 transduced with recombinant adenovirus
Makoto Kataoka, Yuki Terashima, et al.（全7名）
Drug Metab. Pharmacokinet.28 ( 2 ) 125 - 131 2012.08
Joint Work
Research paper (scientific journal)
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ナノテクノロジーは革新的な経口ドラッグデリバリーシステムの開発に貢献できるか
藤井義峰（全2名）
分子消化器病9 ( 2 ) 145 - 150 2012.06
Joint Work
Research paper (scientific journal)
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Dynamic analysis of GI absorption and hepatic distribution processes of telmisartan in rats using positron emission tomography
Makoto Kataoka, Tadayuki Takashima, et al.（全12名）
Pharm. Res.29 ( 9 ) 2419 - 2431 2012.05
Joint Work
Research paper (scientific journal)
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Involvement of functional groups on the surface of carboxyl group-terminated polyamidoamine dendrimers bearing arbutin in inhibition of Na+/glucose cotransporter 1 (SGLT1)-mediated D-glucose uptake
Shun Kanamitsu, Yumi Teraoka, et al.
Mol. Pharmaceutics9 ( 4 ) 922 - 929 2012.03
Joint Work
Research paper (scientific journal)
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Performance of cell-penetrating peptide-linked polymers physically mixed with poorly membrane-permeable molecules on cell membranes
Masaya Suita, Takafumi Yamamoto, et al.
Eur. J. Pharm. Biopharm.81 ( 1 ) 64 - 73 2012.01
Joint Work
Research paper (scientific journal)
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Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form
Yoshimine Fujii, Taro Kanamaru, et al.
Int. J. Pharm.421 ( 2 ) 244 - 251 2011.12
Joint Work
Research paper (scientific journal)
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Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective
Shinji Yamashita, Ken-ichiro Hiwatari, et al.
Curr. Drug Discov. Technol.8 ( 4 ) 367 - 378 2011.12
Joint Work
Research paper (scientific journal)
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Application of dissolution/permeation system for evaluation of formulation effect on oral absorption of poorly water-soluble drugs in drug development
Makoto Kataoka, Kiyohiko Sugano, et al.
Pharm. Res.29 ( 6 ) 1485 - 1494 2011.12
Joint Work
Research paper (scientific journal)
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Estimation of P-glycoprotein-mediated efflux in oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation
Makoto Kataoka, Tomonori Yokoyama, et al.
Eur. J. Pharm. Sci.44 ( 4 ) 544 - 551 2011.11
Joint Work
Research paper (scientific journal)
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Essence of affinity and specificity of peanut agglutinin-immobilized fluorescent nanospheres with surface poly(N-vinylacetamide) chains for colorectal cancer
Haruki Higashino, Hitomi Oshitani, et al.
Eur. J. Pharm. Biopharm.79 ( 3 ) 537 - 543 2011.11
Joint Work
Research paper (scientific journal)
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A perspective for biowaivers of human bioequivalence studies on the basis of the combination of the ratio of AUC to the dose and the biopharmaceutics classification system
Hidehisa Tachiki, Hitoshi Uchiyama, et al.
Mol. Pharmaceutics8 ( 4 ) 1113 - 1119 2011.08
Joint Work
Research paper (scientific journal)
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Scale-up of in vitro permeation assay data to human intestinal permeability using pore theory
Makoto Kataoka, Katsuaki Iwai, et al.
Int. J. Pharm.414 ( 1月2日 ) 69 - 76 2011.07
Joint Work
Research paper (scientific journal)
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Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug
Shaoling Zhang, Kohsaku Kawakami, et al.
Mol. Pharmaceutics8 ( 4 ) 807 - 813 2011.06
Joint Work
Research paper (scientific journal)
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A potential of peanut agglutinin-immobilized fluorescent nanospheres as a safe candidate of diagnostic drugs for colonoscopy.
Makoto Kataoka, Haruki Higashino, et al.
Eur. J. Pharm. Sci.42 ( 4 ) 340 - 347 2011.03
Joint Work
Research paper (scientific journal)
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In vitro dissolution/permeation system to predict the oral absorption of poorly water-soluble drugs: effect of food and dose strength on it.
Makoto Kataoka, Sachi Itsubata, et al.
Biol. Pharm. Bull.34 ( 3 ) 401 - 411 2011.03
Joint Work
Research paper (scientific journal)
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Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant.
Yoshimine Fujii, Taro Kanamaru, et al.
Eur. J. Pharm. Sci.42 ( 4 ) 392 - 399 2011.03
Joint Work
Research paper (scientific journal)
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Imaging of gastrointestinal absorption process of orally administered drugs using positron emission tomography.
Tadayuki Takashima, Makoto Kataoka, et al.
J. Nucl. Med.52 ( 2 ) 249 - 256 2011.02
Joint Work
Research paper (scientific journal)
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食後の吸収率低下の回避を目的とした新規製剤の開発：高pH溶解型腸溶性高分子の利用
丹野 史枝、小久保 宏恭、山下 伸二
Drug Delivery System25 ( 4 ) 384 - 391 2010.08
Joint Work
Research paper (scientific journal)
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Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake.
Yumi Teraoka, Tomokazu Sagawa, et al.
Eur. J. Pharm. Biopharm.75 ( 3 ) 366 - 374 2010.08
Joint Work
Research paper (scientific journal)
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レクチン固定化蛍光ナノスフェアを用いた大腸がんの超早期診断法の開発
日渡 謙一郎、ロバート ホフマン、山下 伸二
Drug Delivery System25 ( 4 ) 403 - 410 2010.08
Joint Work
Research paper (scientific journal)
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Detection of early colorectal cancer imaged with peanut agglutinin-immobilized fluorescent nanospheres having surface poly(N-vinylacetamide) chains.
Takanori Yano, Yoshie Masaoka, et al.
Eur. J. Pharm. Biopharm.74 ( 3 ) 451 - 460 2010.03
Joint Work
Research paper (scientific journal)
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Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes.
Koji Yano, Yoshie Masaoka, et al.
J. Pharm. Sci.99 ( 3 ) 1336 - 1345 2010.03
Joint Work
Research paper (scientific journal)
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Correlation between in vitro dissolution profiles from enteric-coated dosage forms and in vivo absorption in rats for high-solubility and high-permeability model drugs.
Ryoko Ogura, Yoshie Masaoka, et al.
J. Pharm. Sci.98 ( 11 ) 4141 - 4152 2009.11
Joint Work
Research paper (scientific journal)
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In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells.
Takanori Yano, Yoshie Masaoka, et al.
J. Control. Release134 ( 1 ) 2月10日 2009.02
Joint Work
Research paper (scientific journal)
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Stabilization of enzyme-susceptible glucoside bonds of phloridzin through conjugation with poly(γ-glutamic acid).
Tomokazu Sagawa, Yoshie Masaoka, et al.
J. Control. Release133 ( 2 ) 125 - 131 2009.01
Joint Work
Research paper (scientific journal)
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Site-specific drug delivery to the middle-to-lower region of the small intestine reduces food-drug interactions that are responsible for low drug absorption in the fed state.
Fumie K. Tanno, Yoshie Masaoka, et al.
J. Pharm. Sci.97 ( 12 ) 5341 - 5353 2008.12
Joint Work
Research paper (scientific journal)
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Poly(N-vinylacetamide) chains enhance lectin-induced biorecognition through the reduction of nonspecific interactions with non-targets.
Ken-ichiro Hiwatari, Kiyoko Iwata, et al.
Eur. J. Pharm. Biopharm.70 ( 2 ) 453 - 461 2008.10
Joint Work
Research paper (scientific journal)
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Site-specific drug delivery to the middle region of the small intestine by application of enteric coating with hypromellose acetate succinate (HPMCAS).
Fumie K. Tanno, Yoshie Masaoka, et al.
J. Pharm. Sci.97 ( 7 ) 2665 - 2679 2008.07
Joint Work
Research paper (scientific journal)
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Scaling of in vitro membrane permeability to predict P-glycoprotein-mediated drug absorption in vivo.
Yoshiyuki Shirasaka, Yoshie Masaoka, et al.
Drug Metab. Dispo.36 ( 5 ) 916 - 922 2008.05
Joint Work
Research paper (scientific journal)
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Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na+/glucose cotransporter (SGLT1) in the small intestine.
Yusuke Ikumi, Toshiyuki Kida, et al.
J. Control. Release125 ( 1 ) 42 - 49 2008.01
Joint Work
Research paper (scientific journal)
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Conjugation of poorly absorptive drugs with mucoadhesive polymers for the improvement of oral absorption of drugs.
Takaomi Matsumoto, Shinji Yamashita, et al.
J. Control. Release123 ( 3 ) 195 - 202 2007.11
Joint Work
Research paper (scientific journal)
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Effect of administration site in the gastrointestinal tract on bioavailability of poorly absorbed drugs taken after a meal.
Fumie K. Tanno, Yoshie Masaoka, et al.
J. Control. Release118 ( 1 ) 59 - 64 2006.12
Joint Work
Research paper (scientific journal)
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Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract.
Yoshie Masaoka, Yusuke Tanaka, et al.
Eur. J. Pharm. Sci.29 ( 3月4日 ) 240 - 250 2006.11
Joint Work
Research paper (scientific journal)
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Effect of food intake on the oral absorption of poorly water-soluble drugs: in vitro assessment of drug dissolution and permeation assay system.
Makoto Kataoka, Yoshie Masaoka, Shinji Yamashita
J. Pharm. Sci.95 ( 9 ) 2051 - 2061 2006.04
Joint Work
Research paper (scientific journal)