Papers - SAKUMA Shinji

Validation of the absorption-enhancing ability of oligoarginines grafted onto a backbone of hyaluronic acid through animal studies from rodents to primates

Haruya Yagi, Takumi Tomono, Koji Abe, Yasuhiro Tsutsumi, Muneyoshi Makabe, Hiromi Mitsuhashi, Takayuki Kimura, Hideo Kobayashi, Kohei Miyata, Koichi Shigeno, Shinji Sakuma

Mol. Pharmaceutics21 ( 7 ) 3485 - 3501   2024.05

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Mucosal absorption of antibody drugs enhanced by cell-penetrating peptides anchored to a platform of polysaccharides

Takumi Tomono, Haruya Yagi, Ryoji Igi, Akihiro Tabaru, Koichi Fujimoto, Kaho Enomoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma

Int. J. Pharm.647   123499   2023.10

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Performance of cell-penetrating peptides anchored to polysaccharide platforms applied via various mucosal routes as an absorption enhancer

Haruya Yagi, Takumi Tomono, Yuma Handa, Natsuki Saito, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma

Mol. Pharmaceutics20 ( 1 ) 303 - 313   2022.12

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Acquisition of absorption-enhancing abilities of cationic oligopeptides with short chain arginine residues through conjugation to hyaluronic acid

Takumi Tomono, Haruya Yagi, Saki Kanemoto, Masami Ukawa, Kohei Miyata, Koichi Shigeno, Shinji Sakuma

Int. J. Pharm.616   121519   2022.01

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Nasal absorption enhancement of protein drugs independent to their chemical properties in the presence of hyaluronic acid modified with tetraglycine-L-octaarginine

Takumi Tomono, Haruya Yagi, Masami Ukawa, Seiya Ishizaki, Takahiro Miwa, Mao Nonomura, Ryoji Igi, Hironori Kumagai, Kohei Miyata, Etsuo Tobita, Hideo Kobayashi, Shinji Sakuma

Eur. J. Pharm. Biopharm.154   186 - 194   2020.07

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

DOI

Biocompatible polymers modified with D-octaarginine as an absorption enhancer for nasal peptide delivery

Kohei Miyata, Masami Ukawa, Kohta Mohri, Kozue Fujii, Mako Yamada, Sohei Tanishita, Satoshi Higashitarumi, Seiya Ishizaki, Hironori Kumagai, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Koichi Shigeno, Etsuo Tobita, Hideo Kobayashi, Shinji Sakuma

Bioconjugate Chem.29   1748 - 1755   2018.04

Joint Work

Research paper (scientific journal)

Authorship: Corresponding author

Oligoarginine-linked polymers as a new class of penetration enhancers.

Shinji Sakuma, Masaya Suita, Yoshie Masaoka, Makoto Kataoka, Noriko Nakajima, Norihiro Shinkai, Hitoshi Yamauchi, Ken-ichiro Hiwatari, Hiroyuki Tachikawa, Ryoji Kimura, Shinji Yamashita

J. Control. Release148 ( 2 ) 187 - 196   2010.12

Joint Work

Research paper (scientific journal)

Authorship: Lead author  Corresponding author

Impact of Composition of Lipid-Based Formulations on First-Pass Drug Metabolism after Oral Administration

Yusuke Tanaka, Rikuto Fukaishi, Daiki Okamoto, Takanori Kurakazu, Tokio Nakai, Haruya Yagi, Shinji Sakuma

Mol. Pharmaceutics22 ( 4 ) 2098 - 2107   2025.03

Joint Work

Research paper (scientific journal)

DOI

The Improved Antigen Uptake and Presentation of Dendritic Cells Using Cell-Penetrating D-octaarginine-Linked PNVA-co-AA as a Novel Dendritic Cell-Based Vaccine

Yuri Fujioka, Hideto Ueki, Ruhan, Akari Sasajima, Takumi Tomono, Masami Ukawa, Haruya Yagi, Shinji Sakuma, Koichi Kitagawa, Toshiro Shirakawa

Int. J. Mol. Sci.25   5997   2024.05

Joint Work

Research paper (scientific journal)

DOI

In vitro digestion–in situ absorption setup employing a physiologically relevant value of the membrane surface area/volume ratio for evaluating performance of lipid-based formulations: A comparative study with an in vitro digestion–permeation model

Yusuke Tanaka, Hinata Arai, Aya Hidaka, Saki Noda, Ko Imai, Fumiya Tsujisawa, Haruya Yagi, Shinji Sakuma

Mol. Pharmaceutics21 ( 7 ) 3459 - 3470   2024.05

Joint Work

Research paper (scientific journal)

Authorship: Last author 

DOI

Evaluation of a D-octaarginine-linked polymer as a transfection tool for transient and stable transgene expression in human and murine cell lines

Saki Sakuma, Mariko Okamoto, Nao Matsushita, Masami Ukawa, Takumi Tomono, Keiko Kawamoto, Teruo Ikeda, Shinji Sakuma

J. Vet. Med. Sci.84 ( 4 ) 484 - 493   2022.02

Joint Work

Research paper (scientific journal)

DOI

Mechanism on antigen delivery under mucosal vaccination using cell-penetrating peptides immobilized at multiple points on polymeric platforms

Masami Ukawa, Rikito Endo, Haruya Yagi, Takumi Tomono, Kohei Miyata, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma

Int. J. Pharm.613   121376   2021.12

Joint Work

Research paper (scientific journal)

DOI

Polypod-like structured guanine-rich oligonucleotide aptamer as a selective and cytotoxic nanostructured DNA to cancer cells

Kohta Mohri, Emi Hayashi, Manato Nishino, Nao Matsushita, Sohei Tanishita, Makiya Nishikawa, Shinji Sakuma

J. Drug Targeting29 ( 2 ) 217 - 224   2020.10

Joint Work

Research paper (scientific journal)

DOI

Cross-protective abilities of hyaluronic acid modified with tetraglycine-L-octaarginine as a mucosal adjuvant against infection with heterologous influenza viruses

Sohei Tanishita, Masami Ukawa, Takumi Tomono, Yuki Yoshida, Takumi Tsujioka, Kohei Miyata, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma

Bioconjugate Chem.30 ( 12 ) 3028 - 3037   2019.11

Joint Work

Research paper (scientific journal)

DOI

Biodegradable hyaluronic acid modified with tetraglycine-L-octaarginine as a safe adjuvant for mucosal vaccination

Masami Ukawa, Sohei Tanishita, Haruya Yagi, Yuki Yoshida, Takumi Tomono, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma

Mol. Pharmceutics16   1105 - 1118   2019.02

Joint Work

Research paper (scientific journal)

Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues

Hironori Kumagai, Kosuke Yamada, Kanako Nakai, Tokio Kitamura, Kohta Mohri, Masami Ukawa, Takumi Tomono, Takaaki Eguchi, Testuya Yoshizaki, Takumi Fukuchi, Takuya Yoshino, Minoru Matsuura, Etsuo Tobita, Wellington Pham, Hiroshi Nakase, Shinji Sakuma

Eur. J. Pharm. Biopharm.136   29 - 37   2019.01

Joint Work

Research paper (scientific journal)

Specific molecular recognition as a strategy to delineate tumor margin using topically applied fluorescence embedded nanoparticles

Shawn Barton, Bo Li, Michael Siuta, Vaibhav A Janve, Jessica Song, Clinton M. Holt, Takumi Tomono, Masami Ukawa, Hironori Kumagai, Etsuo Tobita, Kevin Wilson, Shinji Sakuma, Wellington Pham

Prec. Nanomed.1 ( 3 ) 194 - 207   2018.10

Joint Work

Research paper (scientific journal)

Phase separation of supersaturated solution created from amorphous solid dispersions: Relevance to oral absorption

Kohsaku Kawakami, Keiko Sato, Mayuko Fukushima, Aoi Miyazaki, Yuko Yamamura, Shinji Sakuma

Eur. J. Pharm. Biopharm.132   146 - 156   2018.09

Joint Work

Research paper (scientific journal)

Effects of the chemical structures of oligoarginines conjugated to biocompatible polymers as a mucosal adjuvant on antibody induction in nasal cavities

Kohta Mohri, Kohei Miyata, Tomomi Egawa, Sohei Tanishita, Rikito Endo, Haruya Yagi, Masami Ukawa, Kyohei Ochiai, Ken-ichiro Hiwatari, Kazufumi Tsubaki, Koichi Shigeno, Etsuo Tobita, Tomofumi Uto, Masanori Baba, Shinji Sakuma

Chem. Pharm. Bull.66 ( 4 ) 375 - 381   2018.04

Joint Work

Research paper (scientific journal)

Elucidation of the mechanism of increased activity of immunostimulatory DNA by the formation of polypod-like structure

Kohta Mohri, Kengo Nagata, Shozo Ohtsuki, Shiori Toyama, Mao Nonomura, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa, Shinji Sakuma

Pharm. Res.34 ( 11 ) 2362 - 2370   2017.08

Joint Work

Research paper (scientific journal)