Papers - KIMURA Tomoki
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Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor, FG4592, Induces Endogenous Metallothionein3 Expression in Human Neuronal Cell Line, ReNcell CX Cells
Mizuki Tsuru, Taisei Ito, Kazuki Komai, Fukuto Kunitomo, Yukie Nakayama, Takanori Murakami, Kazuki Ohuchi, Yasuhiro Shinkai, Tomoki Kimura, Nobuhiko Miura, Yoshito Kumagai, Isao Hozumi, Masatoshi Inden, Hisaka Kurita
Biological and Pharmaceutical Bulletin48 ( 2 ) 137 - 143 2024.02
Joint Work
Research paper (scientific journal)
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he Difference in Zinc Concentrations Required for Induction among Metallothionein Isoforms Can Be Explained by the Different MTF1 Affinities to MREs in Its Promoter
Shoko Ogushi, Tomoki Kimura
International Journal of Molecular Sciences 2022.12
Joint Work
Research paper (scientific journal)
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Cadmium inhibits differentiation of human trophoblast stem cells into extravillous trophoblasts and disrupts epigenetic changes within the promoter region of the HLA-G gene
Shoko Ogushi, Tsuyoshi Nakanishi, Tomoki Kimura
Toxicological Sciences 2022.11
Joint Work
Research paper (scientific journal)
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Cadmium inhibits forskolin-induced differentiation of human placental BeWo cells
Shoko Ogushi, Tsuyoshi Nakanishi, Tomoki Kimura
The Journal of Toxicological Sciences 2022.08
Joint Work
Research paper (scientific journal)
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Discovery of contaminants with antagonistic activity against retinoic acid receptor in house dust
Yingting Jia, Hong Zhang, Wenxin Hu, Lei Wang, Qiyue Kang, Jiaying Liu, Tsuyoshi Nakanishi, Youhei Hiromori, Tomoki Kimura, Shu Tao, Jianying Hu
Journal of Hazardous Materials426 127847 2021.11
Joint Work
Research paper (scientific journal)
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Influence of light–dark cycle on delayed recovery from isoflurane anesthesia induced by hypnotics in mice
Atsunobu Sugano, Hiroki Murai, Syunpei Horiguchi, Yuma Yoshimoto, Yuki Amano, Tomoki Kimura, Yoshinori Iba
Journal of Pharmacological Sciences145 ( 4 ) 335 - 339 2021.02
Joint Work
Research paper (scientific journal)
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CpG site-specific regulation of metallothionein-1 gene expression
Shoko Ogushi, Yuya Yoshida, Tsuyoshi Nakanishi, Tomoki Kimura
International Journal of Molecular Sciences21 ( 17 ) 5946 2020.08
Joint Work
Research paper (scientific journal)
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Tri-substituted organotin compounds, but not retinoic acid, are potent ligands of complement component 8 γ
Katsuya Yamamoto, Youhei Hiromori, Daisuke Matsumaru, Yoichiro Ishii, Yuki Takeshita, Iori Tsubakihara, Tomoki Kimura, Hisamitsu Nagase, Tsuyoshi Nakanishi
The Journal of Toxicological Sciences45 ( 9 ) 581 - 587 2020.06
Joint Work
Research paper (scientific journal)
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The Challenges of Regional Collaboration Based on Fermentation Technology and Their Applications on Education
Yoshiaki Nishiya, Yoshinori Iba, Tomoki Kimura, Eishi Funakoshi
摂南大学地域総合研究所報5 2 - 14 2020.03
Joint Work
Research paper (bulletin of university, research institution)
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Cadmium Inhibits All-Trans-Retinoic Acid-Induced Increase of Nitroblue Tetrazolium Reduction Activity and Induces Metallothionein 1G Expression in Human Acute Myelocytic Leukemia HL-60 Cells
Shoko Ogushi, Shuji Ikemoto, Nobuhiko Miura, Tsuyoshi Nakanishi, Tomoki Kimura
BPB Reports3 ( 1 ) 34 - 38 2020.02
Joint Work
Research paper (scientific journal)
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A simple method using anesthetics to test effects of sleep-inducing substances in mice
Hiroki Murai, Hiroto Suzuki, Hirochi Tanji Tomoki Kimura, Yoshinori Iba
Journal of Pharmacological Sciences142 ( 2 ) 79 - 82 2019.12
Joint Work
Research paper (scientific journal)
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Screening of house dust from chinese homes for chemicals with liver X receptors binding activities and characterization of atherosclerotic activity using an in vitro macrophage cell line and ApoE-/- mice
Wenxin Hu, Yingting Jia, Qiyue Kang, Hui Peng, Haojia Ma, Shiyi Zhang, Youhei Hiromori, Tomoki Kimura, Tsuyoshi Nakanishi, Lemin Zheng, Yifu Qiu, Zhaobin Zhang, Yi Wan, and Jianying Hu
Environmental Health Perspectives 127 ( 11 ) 117003 2019.11
Joint Work
Research paper (scientific journal)
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In vivo profiling of 2,3,7,8-tetrachlorodibenzo-p-dioxin–induced estrogenic/anti-estrogenic effects in female estrogen-responsive reporter transgenic mice
Ichiro Yoshida, Keishi Ishida, Hiroshi Yoshikawa, Sho Kitamura, Youhei Hiromori, Yasushi Nishioka, Akiko Ido, Tomoki Kimura, Jun-ichi Nishikawa, Jianying Hu, Hisamitsu Nagase, Tsuyoshi Nakanishi
Journal of Hazardous Materials385 121526 2019.10
Joint Work
Research paper (scientific journal)
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Long-term cadmium exposure enhances metallothionein-1 induction after subsequent exposure to high concentrations of cadmium in P1798 mouse lymphosarcoma cells
Tomoki Kimura, Takuomi Hosaka, Tsuyoshi Nakanishi, Osamu Aozasa
The Journal of Toxicological Sciences44 ( 4 ) 309 - 316 2019.04
Joint Work
Research paper (scientific journal)
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Low-Concentration Tributyltin Decreases GluR2 Expression via Nuclear Respiratory Factor-1Inhibition
Keishi Ishida, Kaori Aoki, Tomoko Takishita, Masatsugu Miyara, Shuichiro Sakamoto, Seigo Sanoh, Tomoki Kimura, Yasunari Kanda, Shigeru Ohta, Yaichiro Kotake
International Journal of Molecular Sciences18 ( 1754 ) 1 - 16 2017.08
Joint Work
Research paper (scientific journal)
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Metal-mediated Epigenetic Regulation of Gene Expression
Tomoki Kimura
Yakugaku Zasshi137 ( 3 ) 273 - 279 2017.03
Single Work
Research paper (scientific journal)
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Ligand Activity of Group 15 Compounds Possessing Triphenyl Substituent for the RXR and PPARγ Nuclear Receptors
Youhei Hiromori, Akiko Ido, Akira Aoki, Tomoki Kimura, Hisamitsu Nagase, Tsuyoshi Nakanishi
Biological and Pharmaceutical Bulletin39 ( 10 ) 1 - 8 2016.10
Joint Work
Research paper (scientific journal)
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Male Hypogonadism Causes Obesity Associated with Impairment of Hepatic Gluconeogenesis in Mice
Akira Aoki, Kohei Fujitani, Kohei Takagi, Tomoki Kimura, Hisamitsu Nagase, Tsuyoshi Nakanishi
Biological and Pharmaceutical Bulletin39 ( 4 ) 587 - 592 2016.04
Joint Work
Research paper (scientific journal)
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Zinc diethyldithiocarbamate as an inducer of metallothionein in cultured vascular endothelial cells
Tomoya Fujie, Yukino Segawa, Akane Uehara, Takehiro Nakamura, Tomoki Kimura, Eiko Yoshida, Chika Yamamoto, Masanobu Uchiyama, Hiroshi Naka, Toshiyuki Kaji
The Journal of Toxicological Sciences41 ( 2 ) 225 - 232 2016.03
Joint Work
Research paper (scientific journal)
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Induction of metallothionein isoforms by copper diethyldithiocarbamate in cultured vascular endothelial cells
Tomoya Fujie, Yukino Segawa, Eiko Yoshida, Tomoki Kimura, Yasuyuki Fujiwara, Chika Yamamoto, Masahiko Satoh, Hiroshi Naka, Toshiyuki Kaji
The Journal of Toxicological Sciences 41 ( 2 ) 225 - 232 2016.03
Joint Work
Research paper (scientific journal)
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Partial contribution of the Keap1-Nrf2 system to cadmium-mediated metallothionein expression in vascular endothelial cells.
Yasuhiro Shinkai, Tomoki Kimura, Ayaka Itagaki, Chika Yamamoto, Keiko Taguchi, Masayuki Yamamoto, Yoshito Kumagai, Toshiyuki Kaji
Toxicology and Applied Pharmacology295 ( 1 ) 37 - 46 2016.03
Joint Work
Research paper (scientific journal)
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The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective.
Tomoki Kimura, Taiho Kambe
International Journal of Molecular Sciences17 ( 3 ) 336 2016.03
Joint Work
Research paper (scientific journal)
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Chromium (VI)-induced transformation is enhanced by Zn deficiency in BALB/c 3T3 cells
Tomoki Kimura, Akira Onodera, Fumika Okumura, Tsuyoshi Nakanishi, Norio Itoh
The Journal of Toxicological Sciences40 ( 3 ) 383 - 387 2015.02
Joint Work
Research paper (scientific journal)
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Self-Improvement and Participatory Career Development Education Program: Internship and Volunteer Training Experience for Pharmacy Students Results of the training experience verified with follow-up survey three years after participation
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YAKUGAKU ZASSHI134 ( 11 ) 1199 - 1208 2014.07
Joint Work
Research paper (scientific journal)
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Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway
Shigeyuki Fujimoto , Naoya Itsumura , Tokuji Tsuji, Yasumi Anan, Natsuko Tsuji, Yasumitsu Ogra, Tomoki Kimura, Yusaku Miyamae, Seiji Masuda, Masaya Nagao, Taiho Kambe
PLoS One8 ( 10 ) e77445 2013.10
Joint Work
Research paper (scientific journal)
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Bis(L-cysteinato)zincate(II) as a coordination compound that induces metallothionein gene transcription without inducing cell-stress-related gene transcription
Tomoki Kimura, Kengo Yoshida, Chika Yamamoto, Minako Suzuki, Tomoko Uno, Masakazu Isobe, Hiroshi Naka, Shuji Yasuike, Masahiko Satoh, Toshiyuki Kaji, Masanobu Uchiyama
Journal of Inorganic Biochemistry117 140 - 146 2012.12
Joint Work
Research paper (scientific journal)
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Role of megalin and the soluble form of its ligand RAP in Cd-metallothionein endocytosis and Cd-metallothionein-induced nephrotoxicity in vivo
Akira Onodera, Miyuki Tani, Toshimi Michigami, Masayo Yamagata, Kyong-Son Min, Keiichi Tanaka, Tsuyoshi Nakanishi, Tomoki Kimura, Norio Itoh
Toxicology Letters212 91 - 96 2012.05
Joint Work
Research paper (scientific journal)
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Possible aryl hydrocarbon receptor-independent pathway of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced antiproliferative response in human breast cancer cells.
Hiroki Yoshioka, Youhei Hiromori, Akira Aoki, Tomoki Kimura, Yoshiaki Fujii-Kuriyama, Hisamitsu Nagase, Tsuyoshi Nakanishi
Toxicology Letters211 ( 3 ) 257 - 265 2012.04
Joint Work
Research paper (scientific journal)
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Chromium (VI) inhibits mouse metallothionein-I gene transcription by modifying the transcription potential of the co-activator p300
Tomoki Kimura, Fumika Okumura, Akira Onodera, Tsuyoshi Nakanishi, Norio Itoh, Masakazu Isobe
The Journal of Toxicological Sciences36 ( 2 ) 173 - 180 2011.04
Joint Work
Research paper (scientific journal)
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Caspase-4 Directly Activates Caspase-9 in Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells
Akiko Yamamuro, Takashi Kishino, Yu Ohshima, Yasuhiro Yoshioka, Tomoki Kimura, Atsushi Kasai, Sadaaki Maeda
Journal of Pharmacological Sciences115 ( 2 ) 239 - 243 2011.01
Joint Work
Research paper (scientific journal)
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The zinc-sensing transcription factor MTF-1 mediates zinc-induced epigenetic changes in chromatin of the mouse metallothionein-I promoter
Fumika Okumura, Yong Li, Norio Itoh, Tsuyoshi Nakanishi, Masakazu Isobe, Glen K.Andrews, Tomoki Kimura
Biochim Biophys Acta - Gene Regulatory Mechanisms1809 ( 1 ) 56 - 62 2011.01
Joint Work
Research paper (scientific journal)
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Molecular mechanisms of zinc-mediated induction and chromium(VI)-mediated inhibition of mouse metallothionein-I gene transcription
Tomoki Kimura
Journal of Health Science56 ( 2 ) 161 - 166 2010.04
Single Work
Research paper (scientific journal)
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Mechanisms of heavy metal sensing by metal response element-binding transcription factor-1
Tomoki Kimura, Norio Itoh, Glen K. Andrews
Journal of Health Science55 484 - 494 2009.08
Joint Work
Research paper (scientific journal)
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Ethanol-induced expression of glutamate-cysteine ligase catalytic subunit gene is mediated by NF-kappaB.
Tomoki Kimura, Yukiko Kawasaki, Fumika Okumura, Tomomichi Sone, Reiko Natsuki, Masakazu Isobe
Toxicology Letters185 110 - 115 2009.03
Joint Work
Research paper (scientific journal)
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Metal response element-binding transcription factor-1 is activated by degradation of metallothionein.
Tomoki Kimura, Fumika Okumura, Ikuyo Oguro, Tsuyoshi Nakanishi, Tomomichi Sone, Masakazu Isobe, Keiichi Tanaka, Norio Itoh
Journal of Health Science55 72 - 76 2009.02
Joint Work
Research paper (scientific journal)
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Chromium (VI) inhibits mouse metallothionein-I gene transcription by preventing the zinc-dependent formation of an MTF-1-p300 complex.
Tomoki Kimura, Yong Li, Fumika Okumura, Norio Itoh, Tsuyoshi Nakanishi, Tomomichi Sone, Masakazu Isobe, Glen K. Andrews
Biochemical Journal415 477 - 482 2008.11
Joint Work
Research paper (scientific journal)
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Engineering expression of polyphosphate confers cadmium resistance in tobacco.
Takeshi Nagata, Tomoki Kimura, Hidemitsu Pan-Hou
Journal of Toxicological Sciences33 371 - 373 2008.08
Joint Work
Research paper (scientific journal)
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Zinc-induced formation of a co-activator complex containing the zinc-sensing transcription factor MTF-1, p300/CBP and Sp1.
Yong Li, Tomoki Kimura, Ryan W. Huyck, John H. Laity, Glen K. Andrews
Molecular and Cellular Biology28 4275 - 4284 2008.07
Joint Work
Research paper (scientific journal)
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Function of metallothionein in gene expression and signal transduction - Newly found protective role of metallothionein.
Tomoki Kimura, Norio Itoh
Journal of Health Science54 ( 3 ) 251 - 260 2008.03
Joint Work
Research paper (scientific journal)
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Metallothionein induction by hypoxia involves cooperative interactions between MTF-1 and HIF-1alpha.
Brian J. Murphy, Tomoki Kimura, Barbara G. Sato, Yihui Shi and Glen K. Andrews
Molecular Cancer Research6 483 - 490 2008.03
Joint Work
Research paper (scientific journal)
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Molecular Mechanism involved in chromium (VI) toxicity
Tomoki Kimura
Yakugaku Zasshi127 ( 12 ) 1957 - 1965 2007.12
Single Work
Research paper (scientific journal)
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Cytokine-induced Metallothionein Expression and Modulation of Cytokine Expression by Metallothionein.
Norio Itoh, Tomoki Kimura
Yakugaku Zasshi127 ( 4 ) 685 - 694 2007.04
Joint Work
Research paper (scientific journal)
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Role of metal-responsive transcription factor-1 (MTF-1) in EGF-dependent DNA synthesis in primary hepatocytes.
Tomoki Kimura, Norio Itoh, Tomomichi Sone, Masuo Kondoh, Keiichi Tanaka, Masakazu Isobe
Journal of Cellular Biochemistry99 485 - 494 2006.10
Joint Work
Research paper (scientific journal)
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The zinc-sensing mechanism of mouse MTF-1 involves linker peptides between the zinc fingers.
Yong Li, Tomoki Kimura, John H. Laity, Glen K. Andrews
Molecular and Cellular Biology26 5580 - 5587 2006.08
Joint Work
Research paper (scientific journal)
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C-Terminal deletion mutant of MRE-binding transcription factor-1 inhibits MRE-driven gene expression
Tomoki Kimura, Norio Itoh, Tomomichi Sone, Keiichi Tanaka, Masakazu Isobe
Journal of Cellular Biochemistry93 609 - 618 2004.10
Joint Work
Research paper (scientific journal)
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Protective effect of zinc against lipoplysaccharide/ D-galactosamine-induced lethality
Tomoki Kimura, Norio Itoh, Miyako Takehara, Ikuyo Oguro, Jun-ichi Ishizaki, Tsuyoshi Nakanishi, Masakazu Isobe, Keiichi Tanaka
Jornal of Health Science ( 49 ) 40 - 44 2003.02
Joint Work
Research paper (scientific journal)
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MRE-binding transcription factor-1 is activated during endotoxemia : a central rore for metallothionein
Tomoki Kimura, Norio Itoh, Miyako Takehara, Ikuyo Oguro, Jun-ichi Ishizaki, Tsuyoshi Nakanishi, Keiichi Tanaka
Toxicology Letters129 77 - 84 2002.03
Joint Work
Research paper (scientific journal)
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Metallothionein-null mice are sensitve to endotoxine/D-galactosamine-induced hepatotoxicity
Tomoki Kimura, Takatoshi Koujitani, Norio Itoh, Miyako Takehara, Ikuyo Oguro, Jun-ichi Ishizaki, Tsuyoshi Nakanishi, Keiichi Tanaka
Journal of Health Science47 310 - 313 2001.06
Joint Work
Research paper (scientific journal)
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Sensitivity of metallothionein-null mice to LPS/D-galactosamine-induced lethality
Tomoki Kimura, Norio Itoh, Miyako Takehara, Ikuyo Oguro, Jun-ichi Ishizaki, Tsuyoshi Nakanishi, Keiichi Tanaka
Biochemical and Biophysical Research Communications280 358 - 362 2001.01
Joint Work
Research paper (scientific journal)
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Hepatic zinc response via metallothionein induction after tumor transplantation
Haruna Tamano, Emi Igasaki, Shuichi Enomoto, Naoto Oku, Norio Itoh, Tomoki Kimura, Keiichi Tanaka, Atsushi Takeda
Biochemical and Biophysical Research Communications270 1140 - 1143 2000.04
Joint Work
Research paper (scientific journal)
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Metallothionein-null mice express altered genes during development
Tomoki Kimura, Ikuyo Oguro, Junya Kohroki, Miyako Takehara, Norio Itoh, Tsuyoshi Nakanishi, Keiichi Tanaka
Biochemical and Biophysical Research Communications270 458 - 61 2000.04
Joint Work
Research paper (scientific journal)
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Metallothionein acts as a cytoprotectant against doxorubicin toxicity
Tomoki Kimura, Isami Fujita, Norio Itoh, Norio Muto, Tsuyoshi Nakanishi, Kyoko Takahashi, Junichi Azuma and Keiichi Tanaka
The Journal of Pharmacology and Experimental Therapeutics292 299 - 302 2000.01
Joint Work
Research paper (scientific journal)
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Tissue accumulation of cadmium following oral administration to metallothionein-null mice
Tomoki Kimura, Norio Itoh, Kyong-Son Min, Isami Fujita, Norio Muto, Keiichi Tanaka
Toxicology Letters99 85 - 90 1998.10
Joint Work
Research paper (scientific journal)
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Metallothionein-independent hepatoprotection by zinc and sakuraso-saponin
Norio Itoh, Tomoki Kimura, Hirokuni Nakanishi Norio Muto, Motomasa Kobayashi, Isao Kitagawa, Keiichi Tanaka
Toxicology Letters93 135 - 140 1997.12
Joint Work
Research paper (scientific journal)