Papers - KONISHI Motomi
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Efficient nose-to-brain delivery of nine residues peptide (JAL-TA9) exhibiting hydrolytic activity against amyloid-β
Yusuke Hatakawa, Akiko Tanaka, Tomoyuki Furubayashi, Hidemasa Katsumi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sakane
European Journal of Pharmaceutics and Biopharmaceutics208 2025.03
Joint Work
Research paper (scientific journal)
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An 11-mer synthetic peptide suppressing aggregation of Aβ25-35 and resolving its aggregated form improves test performance in an Aβ25-35-induced Alzheimer's mouse model
Rina Nakamura, Akira Matsuda, Youichirou Higashi , Yoshihiro Higashi , Motomi Konishi , Motoaki Saito, Toshifumi Akizawa
Biomolecules 14 ( 10 ) 1234 2024.10
Joint Work
Research paper (scientific journal)
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SKGQA, a Peptide Derived from the ANA/BTG3 Protein, Cleaves Amyloid-β with Proteolytic Activity
Yusuke Hatakawa, Rina Nakamura, Toshifumi Akizawa, Motomi Konishi, Akira Matsuda, Tomoyuki Oe, Motoaki Saito, Fumiaki Ito
Biomolecules14 ( 5 ) 586 2024.05
Joint Work
Research paper (scientific journal)
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Five-mer peptides prevent short-term spatial memory defcits in Aβ25-35-induced Alzheimer’s model mouse by suppressing Aβ25-35 aggregation and resolving its aggregate form
Rina Nakamura, Motomi Konishi , Youichirou Higashi , Motoaki Saito, Toshifumi Akizawa
Alzheimer’s Research & Therapy 15 83 2023.04
Joint Work
Research paper (scientific journal)
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Structure–Activity Relationship of 5-mer Catalytides, GSGYR and RYGSG
Rina Nakamura; Toshifumi Akizawa; Motomi Konishi
Biomolecules12 ( 12 ) 2022.11
Joint Work
Research paper (scientific journal)
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Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration
Yusuke Hatakawa, Akiko Tanaka, Tomoyuki Furubayashi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sanane,,
Pharmaceutics13 ( 10 ) pharmaceutics13101673 2021.10
Joint Work
Research paper (scientific journal)
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Amyloid-beta cleavage by ANA-TA9, a synthetic peptide from the ANA/BTG3 Box A region
Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshiyasu Sanane, Akiko Tanaka, Akira Matsuda, Motoaki Saito, Toshifumi Akizawa
Alzheimers Dement (N Y)7 ( 1 ) e12146 2021.03
Joint Work
Research paper (scientific journal)
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JAL-TA9 Inhibits Aggregation of hPrP180-192 through the Cleavage Reaction
R. Nakamura, M. Konishi,Y. Sakaguchi, Y. Hatakawa, T. Akizawa,
J Pharm Pharmacol Res4 ( 2 ) 23 - 33 2020.06
Joint Work
Research paper (scientific journal)
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Evaluation of the proteolytic activity of 5-mer peptides in BoxA region of Tob/BTG family proteins against Amyloid-β fragment peptides
Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa
PEPTIDESCIENCE 2019 ９ - 10 2020.02
Joint Work
Research paper (scientific journal)
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Catalytides derived from the Box A region in the ANA/BTG3 protein cleave amyloid-β fragment peptide
Yusuke Hatakawa, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa
Heliyon5 ( 9 ) 1 - 11 e02454 2019.09
Joint Work
Research paper (scientific journal)
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The Novel Catalytic Peptide, A Synthetic Nona-Peptide (JAL-TA9) Derived from Tob1 Protein, Digests the Amyloid-β Peptide
Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Motoaki Saito, Toshifumi Akizawa
Journal of Royal Science1 ( 2 ) 30 - 35 2019.08
Joint Work
Research paper (scientific journal)
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Comperison of the catalytic activities of 5-mer synthetic peptides derived from Box A region of Tob/BTG family proteins against the amyloid-beta feagment peptides
Rina Nakamura, Motomi Konishi, Youichirou Higashi, Motoaki Saito, Toshifumi Akizawa
Integrative Molecular Medicine6 1 - 4 2019.06
Joint Work
Research paper (scientific journal)
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The discovery of shorter synthetic proteolytic peptides derived from Tob1 protein
Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Yusuke Hatakawa, Toshifumi Akizawa
Peptides116 71 - 77 2019.06
Joint Work
Research paper (scientific journal)
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Effect of Cu2+ on conformational change and aggregation of hPrP180-192 with a V180I mutation of the prion protein
Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Yusuke Hatakawa, Hidenao Toyoda, Toshifumi Akizawa
Biochemical and Biophysical Research Communications 514 ( 3 ) 798 - 802 2019.05
Joint Work
Research paper (scientific journal)
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The effects of Cu2+ on conformational changes of hPrP180-192 dericved from C-terminal region of prion protein
Yuko Sakaguchi, Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Hidenao Toyoda, Toshifumi Akizawa
Biomedical Research on Trace Elements30 ( 1 ) 1 - 8 2019.04
Joint Work
Research paper (scientific journal)
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The Possibility of Creating a Novel Catalytide in PC
Rina Nakamura, Yusuke Hatakawa, Motomi Konishi, Motoaki Saito, Toshifumi Akizawa
PEPTIDESCIENCE 2018 69 - 69 2019.03
Joint Work
Research paper (international conference proceedings)
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Comparison of proteolytic activity of 5-mer peptides derived from BoxA domain of Tob/BTG family proteins
Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
PEPTIDE SCIENCE 2017 102 - 103 2018.02
Joint Work
Research paper (other academic)
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Structure-activity relationship of 5-mer peptides derived from JAL-TA9
Rina Nakamura, Yusuke Hatakawa, Masanari Taniguchi, Motomi Konishi, Toshifumi Akizawa
PEPTIDE SCIENCE 2017 40 - 41 2018.02
Joint Work
Research paper (other academic)
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MMP-7 cleaves amyloid β fragment peptides and copper ion inhibits the degradation.
Masanari Taniguchi, Kazuki Matsuura, Aya Kojima, Motomi Konishi, Toshifumi Akizawa.,
BioMetals30 ( 5 ) 797 - 807 2017.05
Joint Work
Research paper (scientific journal)
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THE SYNTHETIC PEPTIDE DERIVED FROM BOXA REGION IN ANA/BTG3 PROTEIN IS THE SECOND CATALYTIDE CLEAVING THE AMYLOID-β PEPTIDE
Yusuke Hatakawa, Rina Nakamura, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, and Toshifumi Akizawa
Peptide Science 2016 2017.03
Joint Work
Research paper (scientific journal)
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Novel Finding of Serine Protease-Like Peptide
Rina Nakamura, Aya Kojima, Masanari Taniguchi, Motomi Konishi, Miho Tokumasu, Tadashi Yamamoto, Toshifumi Akizawa
Peptide Science 2016 2017.03
Joint Work
Research paper (scientific journal)
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STRACTURAL ANALYSIS OF THE NOVEL HYDROLASE-LIKE PEPTIDE (JAL-TA9)
Rina Nakamura, Motomi Konishi, Emiri Ushijima, Ryuichiro Tanaka, Masanari Taniguchi, Aya Kojima, Tadashi Yamamoto, Toshifumi Akizawa
Proceedings of 34th European Peptide Symposium 2016 & 8th International Peptide Symposium 2017.01
Joint Work
Research paper (international conference proceedings)
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FINDING OF THE NOVEL HYDROLASE-LIKE PEPTIDE (JAL-TA9) DIGESTING Aβ PROTEIN
Akizawa T., Nakamura R., Kojima A., Konishi M., Taniguchi M., Tokumasu M., Yamamoto Y.
Proceedings of 34th European Peptide Symposium 2016 & 8th International Peptide Symposium 2017.01
Joint Work
Research paper (international conference proceedings)
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Structure–activity relationship study at C9 position of kaitocephalin
Yasuno Y., Hamada M., Yoshida Y., Shimamoto K., Shigeri Y., Akizawa T., Konishi M.,Ohfune Y., Shinada T.
Bioorganic & Medicinal Chemistry Letters26 ( 15 ) 3543 - 3546 2016.08
Joint Work
Research paper (scientific journal)
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C-terminal Region of the hPrP Can Be the Core for the Structural Conversion and Aggregation
A Kojima, M Taniguchi, H Toypoda, S Taniguchi, M Konishi,T Akizawa
Peptide Science 2015 217 - 220 2016.03
Joint Work
Research paper (scientific journal)
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Development of ADAM28 Specific Fluorescence-Quenched Substrate for The Diagnosis of Breast and Lung Carcinomas
M Taniguchi, M Tanaka,A Kozima, M Konishi,S Mochizuki, Y Okada, T Akizawa,
Peptide Science 2015 223 - 226 2016.03
Joint Work
Research paper (scientific journal)
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(7S)-Kaitocephalin as a potent NMDA receptor selective ligand
Y. Yasuno, M. Hamada, M. Kawasaki, K. Shimamoto, Y. Shigeri, T. Akizawa, M. Konishi, Y. Ohfune, T. Shinada
Org. Biomol. Chem.14 1206 - 1210 2015.05
Joint Work
Research paper (scientific journal)
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Studies Using Text Mining on the DiSerences in Leading ESects between the KJ and World Cafe Method as Learning Strategies
T.Yasuhara, T.Sone, K.Konishi, T. Kushihata, 他4
YAKUGAKU ZASSHI135 ( 5 ) 753 - 759 2015.05
Joint Work
Research paper (scientific journal)
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Evaluation of a Specific Peptide Substrate for Membrane-Type 1 Matrix Metalloproteinase
M Taniguchi, R Iemura, A Kojima, M Konishi, T Akizawa
PEPTIDE SCIENCE 2014 299 - 302 2015.03
Joint Work
Research paper (scientific journal)
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INTERMOLECULAR INTERACTION OF HUMAN PRION PROTEIN FRAGMENT PEPTIDES
T Akizawa, M Taniguchi,, A KOjima, T Nakai, M Konishi
PEPTIDE SCIENCE 2014: 169 - 172 2015.03
Joint Work
Research paper (scientific journal)
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DIGESTION OF α-SYNUCLEIN FRAGMENT PEPTIDES WITH MATRIX METALLOPROTEINASES AND INHIBITORT EFFECT OF COPPER ION
T.Akizawa、A. Kojima、C. Matsumura, R. Hirose, M. Taniguch, M. Konishi, H. Toypda, Y. Nagai、谷口将済、
PEPTIDE SCIENCE 2014 191 - 194 2015.03
Joint Work
Research paper (scientific journal)
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A Self-improvement and Participatory Career Development Education Program Involving Internships and Volunteer Training Experience for Pharmacy Students: Results Verified in Follow-up Survey Three Years after Participation
W Kurio, M Konishi, T Okuno, T Nakao et al.
YAKUGAKU ZASSHI134 ( 11 ) 1199 - 1208 2014.11
Joint Work
Research paper (scientific journal)
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Aya Kojima, Motomi Konishi, Toshifumi Akizawa
Biomolecules4 ( 2 ) 510 - 526 2014.04
Joint Work
Research paper (scientific journal)
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Development of the Specific Peptide Substrate for ADAM28
T. Akizawa, M. Konishi, S. Mochizuki, Y. Okada
Peptide Science 2013 409 - 412 2014.03
Joint Work
Research paper (scientific journal)
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Practical Chemistry Education Provided by Team-based Learning (TBL) and Peer Evaluation
T Yasuhara, M Konishi, T Nishida, T Kushihata,T Sone, W Kurio, Y Yamamoto, T Nishikawa,K Yanada, M Nakamura
YAKUGAKU ZASSHI134 ( 2 ) 185 - 194 2014.02
Joint Work
Research paper (scientific journal)
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Self-Improvement and Participatory Career Development Education Program:＂Internship and Volunteer Experience Training for Pharmacy Students＂ and its results
Kurio, Konishi, Okuno, Kohno, Ogita, et al.
Japanese Journal of Pharmaceutical Health Care and Sciences38 ( 12 ) 757 - 766 2012.12
Joint Work
Research paper (scientific journal)
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Development of MT1-MMP Specific Peptide Substrate for the Risk Assessment of Cancer Metastasis and Malignancy.
R Okihara, A Kojima, M Nagano, M Konishi, T Akizawa
Peptide Science 2010 266 2012.03
Joint Work
Research paper (scientific journal)
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A Kojima,Y Mabuchi, R Okihara, M Nagano, M Konishi, T Akizawa
Peptide Science 2010 206 2012.03
Joint Work
Research paper (scientific journal)
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Metal-Binding Ability of Human Prion Protein Fragment Peptides Analyzed by Column Switch HPLC.
A Kojima,Y Mabuchi, M Konishi, R Okihara, M Nagano, T Akizawa
Chem. Pharm. Bull.59 ( 8 ) 965 - 971 2011.08
Joint Work
Research paper (scientific journal)
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Metal-Binding Ability of His-Containing Fragment Peptides Originating from Prion Protein Studied by Column Switch HPLC
Aya Kojima, Motomi Konishi, Toshifumi Akizawa
Analytical Sciences59 ( 8 ) 701 - 707 2010.08
Joint Work
Research paper (scientific journal)
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Metal-binding Ability of Peptides Originating from Prion Protein by a Column Switch HPLC
A Kojima, M Konishi,T Akizawa
Peptide Science 2009 223 - 226 2010.03
Joint Work
Research paper (scientific journal)
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Regioselective synthesis of methylated epigallocatechin gallate via nitrobenzensulfonyl (Ns) protecting group
相原義之、吉田篤史、吉田巧、脇本敏幸、秋澤俊史、菅敏幸
Bioorganic & Medicinal Chemistry Letters ( 19 ) 4171 - 4174 2009.08
Joint Work
Research paper (scientific journal)
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Finding of the chaperone peptide (R)
A Kojima, M Konishi, M Nishi, T Akizawa
PEPTIDE SCIENCE2008 277 - 280 2009.03
Joint Work
Research paper (scientific journal)
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Novel digitalis factor,marinobufotoxin,isolated from cultured Y-1 cells,and its hypertensive effect in rats
吉賀正亨、小宮山豊、小西元美、秋澤俊史、高橋伯夫、他５名
Ｈｙｐｅｒｔｅｎｓｉｏｎ 49 ( 1 ) 209 - 214 2007.01
Joint Work
Research paper (scientific journal)
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Enzyme immunoassay of D-3-methoxy-4-hydoroxyphenylglycol in human urines
K Hirose, T Akizawa, M Konishi, A Kakuyama, M Yoshioka, Y Andow, T Hoshino
Biogenic Amines50 ( 5-6 ) 202 - 212 2006.12
Joint Work
Research paper (scientific journal)
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Characterization of a novel metalloproteinase in duvcrnoy's gland of Rhabdophis tigrinus tigrinus (R)
小森浩二、松田明、堀隆光、秋澤俊史、他５名
The Journal of Toxicological Sciences 157 - 168 2006.05
Joint Work
Research paper (scientific journal)
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Synthetic Study of a Cardiac Steroid, Marinoic Acid
Takanori Ochi, Yoshihiro Yamaguchi, Motomi Konishi, Toshifumi Akizawa, Tateaki Wakamiya
J. School Sci. Eng. Kinki Univ. ( 41 ) 17 - 22 2005.06
Joint Work
Research paper (bulletin of university, research institution)
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Purification of Metalloproteinase in Duvrernoy's Glands of Rhabdophis tigrinus by Affinity Column based on Cysteine Switch Mechanis
小森浩二、小西元美、堀隆光、鳥羽道久、堺敦史、秋澤俊史
Peptide Science 2003 477 - 480 2004.03
Joint Work
Research paper (scientific journal)
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(-)-Epigallocatechin gallete inhibits membrare-type 1 matalloproteinase,MTI-MMP and tumor angiogenesis
Satoru Yamakawa, Tomohiro Asai, Takayuki Uchida, Motomi Matsukawa, Toshifumi Akizawa, Naoto Oku
Cancer Letters ( 210 ) 47 - 55 2004
Joint Work
Research paper (scientific journal)
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Amino Acid Sequence as Specific Peptide Struture Tagated Membrane-type│ Metnx Metalloprotage
小西 元美
339 - 342 2004
Research paper (scientific journal)
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A Screenig System of Prodrugs Selective for Mao-A or Mao-B
小西 元美
( 25 ) 293 - 302 2004
Research paper (scientific journal)
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Inhibitory Effect of Green Tea Polyphenols on Membran-Type 1 Metalloproteinase, MTI-MMP
Naoto Oku, Motomi Matsukawa, Satoru Yamakawa, Tomohiro Asai, Shoji Yahara, Fumio Hashimoto, Toshifumi Akizawa
Biol. Pharm. Bulll26 ( 9 ) 1235 - 1238 2003.06
Joint Work
Research paper (scientific journal)
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Inhibitory Effect of Green Tea Polyphenols on Membran-Type 1 Metalloproteinase, MTI-MMP
小西 元美
1235 - 1238 2003
Research paper (scientific journal)
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Study on Peptides Inhibiting the Activation of Gelatinase A (MMP-2)
小西 元美
Peptide Science 20011, 227-230 2002
Research paper (scientific journal)
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Identification of New Ca+ Binding Site on Membrane Type Matrix Metalloproteinases by Using Synthetic Fragment Peptides
Atsuyoshi Nakamoto, Motomi Matsukawa, Yasuhiro Itagaki, Motoharu Seiki, Toshifumi Akizawa
Peptide Science 2001 231 - 234 2002
Joint Work
Research paper (scientific journal)
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Study on Peptides Inhibiting the Activation of Gelatinase A (MMP-2)
小西 元美
1, 227-230 2002
Research paper (scientific journal)
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Identification of New Ca+ Binding Site on Membrance Type Matrix Metalloproteinases by Using Synthetic Fragment Peptides
小西 元美
Peptide Science 20011, 231-234 2002
Research paper (scientific journal)
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Inhibitory Activities of Peptide-Conformers Originating from Matrix Metalloproteinase-7 against MMPS
小西 元美
377 1999
Research paper (scientific journal)
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Development and Application of a Microplate Assay Method for the Mass Screening of MMP Inhibitors
小西 元美
878 622 1999
Research paper (scientific journal)
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Isolation and Characterization of Novel Endogenous Digitalis-like Factors in the Ovary of the Giant Toad, Buformarinus
小西 元美
61 ( 12 ) 1476 1998
Research paper (scientific journal)
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Syntheses and Biological Activities of Joro Spider Toxin Analogs to Spidermine and Joramine
千葉忠成、秋澤俊史、松川元美、河合信史、河野義明、吉岡正則
Chemical & Pharmaceutical Bulletin45 ( 1 ) 93 - 100 1997.01
Joint Work
Research paper (scientific journal)
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Heterogeneity and lability of endogenous digitalis-like substances in the plasma of the toad, Bufo marinus 'jointly worked'
小西 元美
1996
Research paper (scientific journal)
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Marinoic acid, a novel bufadienolide-related substance in the skin of the giant toad, Bufo marinus(共著)
Motomi Matsukawa, Toshifumi Akizawa, Jennifer F. Morris, Vinent P. Butler, Jr., Masanori Yoshioka
Chem. Pharm. Bull.44 ( 1 ) 255 - 257 1996
Joint Work
Research paper (scientific journal)
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Synthesis of PRCGVPD-containing peptides as MMP-7 Inhibitors
Toshifumi Akizawa, Mamoru Osaki, Motomi Matsukawa, Masafumi Hamai, Michiyasu Itoh, Motoharu Seiki, Masanori Yoshioka
Peptide Chemistry 1995 305 - 308 1996
Joint Work
Research paper (scientific journal)
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Total Syntheses of Spidamine and Joramine, Polyamine Toxins from the Joro Spider, Nephila clavata(共著)
小西 元美
44 ( 5 ) 972 - 979 1996
Joint Work
Research paper (scientific journal)
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Large-Scale Purification and Further Characterization of Spidamine and Joramin from Venom of Spider, Nephila clavata(共著)
小西 元美
43 ( 12 ) 2177 - 2181 1995
Joint Work
Research paper (scientific journal)
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Finding of Primitive Polyamine Toxins in the Venom of a Joro Spider, Nephila clavata(共著)
小西 元美
42 ( 9 ) 1864 - 1869 1994
Joint Work
Research paper (scientific journal)
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Structure of novel bufadienolides in the eggs of a toad, Bufo marinus(共著)
小西 元美
42 ( 3 ) 754 - 756 1994
Joint Work
Research paper (scientific journal)
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1H-NMR studies on the proline cisltrans conformers of the synthetic fragment pepticles of membrane-type matrix metalloproteinase
T. Akizawa, T. Ayabe, M Matsukawa, M Itoh, N Nishi, H Sato, M Seiki, M Yoshioka
J. Protein Chem.13 ( 5 ) 483 - 484 1994
Joint Work
Research paper (international conference proceedings)